Objective To investigate the difference between long-term and short-term clinical efficacy of globus pallidus internus(GPi)deep brain stimulation(DBS)in patients with craniocervical dystonia(CCD).Methods 24 patients with refractory craniocervical dystonia who underwent GPi DBS at Xuanwu Hospital,Capital Medical University from January 2016 to December 2023 were analyzed retrospectively.The study assessed the severity and disability of the dystonia with Burke-Fahn-Marsden dystonia rating scale(BFMDRS).The BFMDRS scores were collected before 6 months after and the most recent follow-up visit.Results The initial symptom was blepharospasm in 16 patients,7 presented with cervical dystonia and only 1 started with oromandibular dystonia.The mean follow-up period was 37.5±23.5 months(range 6-84 months).The mean total BFMDRS-M scores at the 3 time points were 13.3±9.4,5.0±4.7(55.3％improvement,P＜0.01),4.5±3.6(56.6％improvement,P＜0.01)respectively.In 5 patients(20.8％),the results qualified as poor(＜30％improvement in BFMDRS).Conclusions The results indicate some long-term efficacy of GPi DBS in treatment of refractory CCD.The clinical outcome is not as stable as we expect,but the overall improvement is rather effective.Patients with specific type of dystonia might consider targets other than GPi for better response.
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