首页|重复经颅磁刺激联合注意力训练治疗精神分裂症的临床疗效

重复经颅磁刺激联合注意力训练治疗精神分裂症的临床疗效

Clinical effectiveness of repeated transcranial magnetic stimulation combined with attention training in the treatment of schizophrenia

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目的 探讨重复经颅磁刺激联合注意力训练治疗精神分裂症的临床疗效.方法 将88例精神分裂症患者按照随机数字表法分为对照组和研究组,各 44 例.对照组患者采用利培酮联合重复经颅磁刺激治疗,研究组患者在对照组基础上给予注意力训练治疗,治疗 4 周.比较两组患者临床疗效、不良反应发生情况,比较治疗前后两组患者重复性成套神经心理状态测验(RBANS)评分、住院精神病患者社会功能评定量表(SSPI)评分及 5-羟色胺(5-HT)水平.结果 治疗后,研究组患者临床疗效总有效率高于对照组(P<0.05).治疗后,两组患者RBANS、SSPI评分较治疗前升高,且研究组高于对照组;5-HT水平较治疗前降低,且研究组低于对照组(P<0.01).两组患者不良反应总发生率比较,差异无统计学意义(P>0.05).结论 重复经颅磁刺激联合注意力训练治疗精神分裂症的临床疗效显著,可较好改善患者临床症状、社会功能及认知功能,且不良反应少,较为安全可靠.
Objective To explore the clinical effectiveness of repeated transcranial magnetic stimulation(rTMS)plus attention training in the treatment of schizophrenia.Methods Eighty-eight schizophrenics were divided into control and research group according to random number table method,with 44 ones in each.Controls were treated with risperidone+rTMS and research group was plus attention training on the basis of controls,for 4 weeks.Such indexes were compared between two groups as clinical effectiveness,the occurrence of adverse reactions,pre-and post-treatment scores on the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS)and Scale of Social function in Psychosis Inpatients(SSPI),and 5-hydroxytryptamine(5-HT)levels.Results After treatment,the clinical total effective rate was higher in research than control group(P<0.05).After treatment,scores on the RBANS and SSPI in both groups elevated compared with pre-treatment and those were higher in research than control group;5-HT levels in both groups lowered compared with pre-treatment and that was lower in research than control group(P<0.01).Intergroup difference in the incidence of adverse reactions weren't statistically significant(P>0.05).Conclusion The combination of rTMS and attention training has a significant effect in the treatment of schizophrenia,can improve clinical symptoms,social function and cognitive function,has fewer adverse reactions,and is safe and reliable.

schizophreniarepeated transcranial magnetic stimulationattention trainingclinical effectiveness

毕雪飞、袁梅菊、胡文中

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471000(河南·洛阳)洛阳市第五人民医院

精神分裂症 重复经颅磁刺激 注意力训练 临床疗效

2025

临床心身疾病杂志
河南省精神病医院(新乡医学院第二附属医院)

临床心身疾病杂志

影响因子:1.01
ISSN:1672-187X
年,卷(期):2025.31(1)