Objective To explore the clinical efficacy of endoscopic electrocoagulation hemostasis(EECH)combined with esomeprazole in the treatment of peptic ulcer bleeding.Methods Ninety-two patients with peptic ulcer bleeding were divided into two groups according to patients'will,with 46 ones in each.Controls received esomeprazole treatment and research group did the EECH plus esomeprazole,for 5 days.Such indexes were compared between two groups as clinical effects,the relief time of clinical symptoms,pre-and post-treatment coagulation functions(prothrombin time[PT],fibrinogen[FIB],activated partial thromboplastin time[APTT]and thrombin time[TT]),and gastric acid secretion(basal acid output[BAO],maximum acid output[MAO]and peak acid output[PAO])before treatment and in a month after treatment.Results The clinical total effective rate was higher in research than control group(91.30%vs.76.09%,P＜0.05).After 5 day treatment,PT,APTT and TT shortened and FIB levels elevated in both groups compared with pre-treatment,and research group was superior to controls(P＜0.01).Relieves of abdominal pain,abdominal distension,hematemesis or hematochezia,and belching were earlier in research than control group(P＜0.01).After 1 month treatment,the BAO,MAO and PAO were lower in both groups compared with pre-treatment and so were those in research than control group(P＜0.05 or 0.01).Conclusion The EECH plus esomeprazole is effective in the treatment of peptic ulcer bleeding,can play a synergistic role and improve clinical symptoms quickly,inhibit gastric acid secretion,protect gastrointestinal mucosa,and accelerate the progress of patients'rehabilitation.
维普
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