Kidd血型相关SLC14A1基因在肾透明细胞癌中的表达及临床意义
Expression of Kidd Blood Group Related SLC14A1 Gene in Kidney Renal Clear Cell Carcinoma and Its Clinical Significance
周仁龙 1钟靖 2唐丹丹3
作者信息
- 1. 深圳市龙华区中心医院输血科 518100
- 2. 邵阳市中心医院输血科 422000
- 3. 深圳市南山区医疗集团总部 518000
- 折叠
摘要
目的 探讨Kidd血型溶质载体家族14基因(solute carrier family 14,SLC14A1)在肾透明细胞(kidney renal clear cell carcinoma,KIRC)中的表达及临床意义.方法 运用生物信息学分析方法,联合SANGERBOX、GEPIA、UALCAN、STRING等数据库分析和评估SLC14A1在KIRC中的表达和临床预后价值.结果 Kidd血型SLC14A1基因在4种肿瘤中观察到了显著上调(P＜0.05),在22种肿瘤中观察到了显著下调(P＜0.05),其中SLC14A1在KIRC组织中mRNA表达水平显著低于正常组织(1.35±1.69 vs 3.90±2.47,P=4.7e-36).生存分析表明,SLC14A1表达水平与KIRC总体生存率呈显著正相关(P＜0.05).基于单因素Cox和多因素Cox回归结果分析低表达SLC14A1是KIRC预后危险因素.KEGG富集分析代谢途径通路占主导地位,GO富集分析吞噬体酸化、三价铁运输、转铁蛋白转运占主导地位.结论 Kidd血型SLC14A1基因在多数KIRC中呈现低表达,与KIRC的发生、发展和预后不良相关,有望作为KIRC诊断、预后判断和治疗靶点.
Abstract
Objective To investigate the expression and clinical significance of Kidd blood group solute carrier family 14(SLC14A1)gene in kidney clear cell carcinoma(KIRC).Methods Bioinformatics analysis was used to analyze and evaluate the expression and clinical prognostic value of SLC14A1 in KIRC in combination with SANGERBOX,GEPIA,UALCAN,STRING and other databases.Results Kidd blood group SLC14A1 gene was significantly up-regulated in 4 tumors(P＜0.05),and significantly down regulated in 22 tumors(P＜0.05).The mRNA expression level of SLC14A1 in KIRC tissues was significantly lower than that in normal tissues(tumor1.35±1.69 vs normal 3.90±2.47,P＜0.05).Survival analysis showed that the expression level of SLC14A1 was significantly positively correlated with the overall survival rate of KIRC(P＜0.05).Based on univariate Cox and multivariate Cox regression analysis,low expression of SLC14A1 was a prognostic risk factor for KIRC.KEGG enrichment analysis dominates in metabolic pathways.GO enrichment analysis dominates in phagosome acidification,trivalent iron transport and transferrin transport.Conclusion The low expression of Kidd blood group SLC14A1 gene in KIRC is associated with the occurrence,development and poor prognosis of KIRC,which is expected to be used as a possible target for KIRC diagnosis,prognosis judgment and treatment.
关键词
肾透明细胞癌/Kidd血型/SLC14A1基因/生物信息学/癌症基因组图谱Key words
Kidney renal clear cell carcinoma/Kidd blood group/SLC14A1 gene/Bioinformatics/TCGA引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据