Objective To analyze whether the supply data of component blood from 25 central blood stations in China was affected by the COVID-19 during 2017 to 2022.Methods The distribution data of red blood cell components,frozen plasma,cryoprecipitate,pathogen inactivation frozen plasma,adjusted red blood cell components,and adjusted frozen plasma from 25 central blood stations in China during 2017-2022 was collected retrospectively.Based on the outbreak time of COVID-19,the distribution data of 2017-2019 was the non-COVID-19 group(referred to as the non-COVID-19 group),and that of 2020-2022 was the COVID-19 group(referred to as the COVID-19 group).Results The distribution amount of red blood cell components increased during 2017 to 2022,namely 2022>2021>2019>2020>2018>2017.There was a decrease of 19 724.12 U from 2019 to 2020,the showing a negative annual growth rate(-1.43%)in 2020,which was significantly correlated with central blood stations(P<0.05).The distribution amount of frozen plasma increased during 2017 to 2022,namely 2022>2021>2020>2019>2018>2017,which was significantly correlated with central blood stations(P<0.05).The distribution of cryoprecipitate basically increased during 2017 to 2022,namely 2021>2022>2020>201 9>2018>2017.There was a decrease of 6 303.72 U from 2021 to 2022,showing a negative annual growth rate(-1.54%)in 2020,which was significantly correlated with central blood stations(P<0.05).The distribution amount of pathogen inactivation frozen plasma increased during 2020 to 2022;the annual growth rate was negative in 2021 and positive in 2022.The distribution amount of adjusted red blood cell components decreased,and the annual growth rate was negative;the distribution amount of adjusted frozen plasma decreased,and the annual growth rate was negative.Conclusion There were significant regional differences in the supply of whole-blood-prepared component blood from the 25 central blood stations in China,and there were different impact degrees by the COVID-19.In general,it had the most significant impact on the supply capacity in 2020.Blood re-distribution was one of the measures to ensure blood supply during the COVID-19 epidemic.