Red blood cell transfusion has been widely used in trauma treatment,surgery,anemia treatment,war wound emergency treatment and other aspects,but there are still problems such as shortage of blood resources,short storage period,cross-matching before transfusion,and possible transmission of pathogens through blood.Hemoglobin-based oxygen carriers(HBOCs)are a class of soluble nano-oxygen carriers prepared by chemical modification of matrix-free hemoglobin,which can replace red blood cells to transport oxygen to organs and tissues in the body.HBOCs have the characteristics of no blood group and virus transmission risk,long storage,and instant use,so they are also known as red blood cell substitutes.This paper aims to review the research progress of HBOCs,and explore their application prospects in organ preservation,cerebral ischemia,tumor treatment and other treatments in addition to the replacement of red blood cell transfusion.
Red Blood Cell SubstitutesHemoglobin oxygen carrierTraumaAnemiaOrgan preservationCerebral ischemiaTumor
国家科技期刊平台
NSTL
万方数据
维普
