Smoking constitutes a significant public health concern,recognized as a leading preventable cause of mortality worldwide.Tobacco smoke carries biologically active substances and toxic compounds that affect human health,leading to shortened lifespans.Oxidative stress induced by smoking exerts negative effects on the quality of red blood cells(RBCs),primarily through membrane damage and increased levels of abnormal hemoglobin.Prolonged smoking leads to abnormalities in various RBC parameters,thereby facilitating the onset and progression of diseases.This paper provides a summary of recent research on the adverse effects of smoking on red blood cells,aiming to furnish additional theoretical groundwork for enhancing tobacco control efforts.