Objective This article statistically analyzed the basic characteristic parameters of blood donors from 2017-2022,for providing reference for the continuousimprovement of blood collection.Methods We Selected 17 provincial blood centres that are members of the blood collection and supply institution practice comparison working group in mainland China,with 15 parameter data reflecting the characteristics of the blood donation population.The data group from 2017-2019 was set as the control group,and 2020-2022 was set as the observation group.The two groups of data were compared using F-test and chi-square.Results The data showed that there were significant changes in 10 parameters(accounting for 66.7%),namely the proportion of young first-time donors(18~24 years old),proportion of first-time donors(≥25 years old),proportion of first-time donors to all donors,participation rate of young donors(18~24 years old),trend of changes in donor base,proportion of donors turnover,rate of the delayed donations number of regular donors per year,number of people who intend to donate,and number of donors who have completed donations.Conclusion From 2017-2022,the blood donation population of 17 provincial-level blood centers in China has characteristics of high proportion of first-time donors to all donors,high turnover rate,and low overall participation rate of donors,etc.,which has a certain continuity compared to previous years,in which the trend of changes in donor base and the rate of delayed donations have significant changes.