Objective To understand the current situation of the genotype database of apheresis platelet donors in China by investigating the size of the genotype database of apheresis platelet donors and the application of gene matching transfusion.Methods The data were collected from the platelet gene database collaboration group by the principle of voluntary reporting,and the data of the genotype database of apheresis platelet donors of 27 blood stations in China in 2022,the data of database establishment and platelet cross-matching in 14 blood stations from 2021-2023 were analyzed.Results By the end of 2022,27 blood stations in China had established platelet HLA genotype databases,with the database capacity ranging from 50 to 23 940,with an average of 3 339±5 915,of which 9 were more than 2 000.The database capacity of platelet HPA genotypes ranged from 50 to 7 162,with an average of 1 636±1549,of which 14 were greater than 1 000.Of the 27 blood stations in China,13 have no CD36 negative blood donors,and 14 have the data of CD36 negative blood donors,with a capacity of 2-280,with an average of 41±73.From 2021 to 2023,the database capacity of HLA and HPA genotypes of platelet donors in China is increasing year by year.The number of platelet cross-matching in 14 blood stations from 2021 to 2023 ranged from 20 to 8 000,but the proportion of gene matching transfusion varied greatly,ranging from 0%to 40%,with an average of less than 10%.Conclusion There are great differences in the size and application of the genotype database of apheresis platelet donors in China.It is urgent to expand the size and improve the utilization rate of the database to realize accurate platelet transfusion and further ensure the scientific validity,effectiveness and safety of clinical blood transfusion.
关键词
血小板基因库/建设/库容量/应用
Key words
Genotype database of platelet donors/Establishment/Capacity/Application
维普
万方数据