In recent years,the mechanisms of platelet aging have garnered increasing attention.With advancements in detection technologies,researchers are now able to study the age stratification of platelets in the peripheral blood of healthy individuals,revealing extensive changes at both the transcriptomic and proteomic levels during the aging process.Pathophysiological studies have further elucidated the critical role of platelets in various diseases,closely associated with age-related changes in platelets.However,the specific characteristics of platelet aging and their precise role in disease development remain to be fully elucidated.Therefore,understanding the physiological characteristics and molecular mechanisms of aging platelets under normal conditions is crucial for research.This review summarizes the transcriptomic and proteomic studies on platelet aging in physiological conditions,as well as the changes in platelet turnover in related diseases,aiming to provide a reference for exploring the relationship between platelet aging and disease development.
万方数据
维普
