摘要
目的 系统分析我国妊娠期妇女血小板抗体阳性率及其影响因素.方法 检索数据库PubMed、CNKI、EMbase、WanFang Data和VIP建库至2024年3月有关中国妊娠期妇女血小板抗体检测的研究文献.文献筛选和资料提取后,进行Meta分析.结果 最终纳入24篇文献,共计41 079名妊娠期妇女,其中2 917名血小板抗体为阳性.妊娠期妇女总血小板抗体阳性率为8.05%.南方地区妊娠期妇女总血小板抗体阳性率为7.14%,低于北方的11.93%(P＜0.01).有妊娠史的妊娠期妇女血小板抗体阳性率为14.13%,高于无妊娠史的3.15%(P＜0.01).1次、2次和≥3次妊娠的妊娠期妇女血小板抗体阳性率分别为3.52%、8.47%和15.18,有明显统计学意义(P＜0.01).孕妇不同分娩方式经阴道产和剖宫产血小板抗体阳性率分别为10.10%和8.49%(P＞0.05).A型、B型、O型和AB型妊娠期妇女血小板抗体阳性率分别为8.86%、7.25%、6.38%和5.55%(P＞0.05).结论 我国妊娠期妇女血小板阳性率与地域、妊娠史和妊娠次数具有相关性,未发现与不同分娩方式以及ABO血型之间的相关性.
Abstract
Objective To evaluate the incidence of platelet antibodies in pregnant women and its influencing factors.Methods The databases PubMed,CNKI,EMbase,WanFang Data and VIP were searched for studies on platelet antibodies detection in pregnant women in China from the establishment of the database to March 2024.Meta-analysis was performed after literature screening and data extraction.Results Twenty-four studies totaling 41 079 pregnant women were finally included,of which 2 917 were positive for platelet antibody.The total platelet antibody positive rate in pregnant women was 8.05%.The total platelet antibody positive rate was 7.14%in the southern region,lower than 11.93%in the northern region(P＜0.01).The positive rate of pregnant women with a history of pregnancy was 14.13%,higher than that of 3.15%in those without pregnancy history(P＜0.01).The positive rates of platelet antibodies in pregnant women with 1,2 and≥3 or more pregnancies were 3.52%,8.47%and 15.18,respectively,with statistically significant differences(P＜0.01).The positive rates of platelet antibody among pregnant women with different modes of delivery were 10.10%and 8.49%for transvaginal and cesarean deliveries,respectively(P＞0.05).The positive rates of platelet antibody in women with type A,B,O and AB were 8.86%,7.25%,6.38%and 5.55%,respectively(P＞0.05).Conclusion The positive rate of platelet antibodies in Chinese pregnant women is correlated with region,pregnancy history and number of pregnancies,but not with delivery modes or ABO blood types.
维普
万方数据