哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种丝/苏氨酸蛋白激酶,在调节细胞的生长、增殖中起着重要的作用.mTOR复合体通过磷酸化激活下游底物S6K1、4E-BP等调节细胞生长、增殖、蛋白质代谢等等,同样mTOR信号通路在造血系统中也发挥重要作用,其整合多种信号对造血干细胞的静止、自我更新和多向分化三个过程起调节作用,本文系统介绍相关信号分子及蛋白如何通过影响mTOR信号通路并进一步影响造血干细胞发挥功能.
Abstract
The mammalian target of rapamycin(mTOR)is a serine/threonine protein kinase that plays an important role in regulating cell growth,proliferation.The mTOR complex regulates cell growth,proliferation,protein metabolism by phosphorylating and activating downstream substrates such as S6K1,4E-BP,etc.The mTOR signalling pathway similarly plays an important role in the haematopoietic system,integrating multiple signals to regulate the three processes of haematopoietic stem cell quiescence,self-renewal and multidirectional differentiation.This article systematically describes how relevant signalling molecules and proteins affect the mTOR signalling pathway and further influence haematopoietic stem cell function.
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