Correlation of dietary inflammation index with sarcopenia in patients with chronic kidney disease based on the NHANES database
Objective To identify the correlation of dietary inflammatory index(DII)with sar-copenia in patients with chronic kidney disease(CKD)based on the National Health and Nutrition Exami-nation Survey(NHANES)database.Methods Data from 1999-2006 and 2012-2018 in the NHANES database were analyzed.DII was calculated from dietary data,and patients were divided into DII Q1,DII Q2,DII Q3,and DII Q4 groups based on DII quartiles.Age,gender and the prevalence of sarcopenia were compared between the groups.Logistic regression model was used to analyze the relationship be-tween DII and sarcopenia in patients with trend and stratification analysis.Restricted cubic spline plots(RCS)were used to analyze a nonlinear relationship between DII and sarcopenia.Results A total of 1,660 CKD patients were included in this study.There was a significant difference in the prevalence of sar-copenia in CKD patients among the DII Q1(42.17%),DII Q2(46.99%),DII Q3(52.05%),and DII Q4(58.80%)groups(χ2=25.224,P＜0.001).After adjusting for confounders,DII was still significantly as-sociated with the risk of sarcopenia in CKD patients(OR=1.214,95%CI:1.135-1.299,P＜0.001).Compared with the DII Q1 group,CKD patients in the DII Q3(OR=1.467,95%CI:1.106-1.948,P=0.008),and DII Q4 groups(OR=1.876,95%CI:1.405-2.511,P＜0.001)had a significantly higher risk of developing sarcopenia,with an increasing odds ratio(OR)(Pfor trend＜0.001).After stratifica-tion,DII remained positively associated with the risk of sarcopenia in female CKD patients(P=0.024).Conclusion DII is strongly associated with the risk of sarcopenia in CKD patients,with higher DII scores associated with a higher risk of developing sarcopenia.
Chronic kidney diseaseSarcopeniaDietary inflammatory indexNational health and nutrition survey database
NETL
NSTL
万方数据
