Research progress of endoplasmic reticulum stress in peritoneal dialysis
Peritoneal dialysis is an effective renal replacement therapy for the treatment of end-stage renal disease.Prolonged peritoneal dialysis is prone to peritoneal inflammation,neoangiogenesis,and fibrosis,ultimately leading to interruption of peritoneal dialysis treatment.Recent studies have found that endoplasmic reticulum(ER)stress is closely related to peritoneal dialysis-associated complications.This article summarized the research progress of ER stress in peritoneal dialysis at home and abroad in re-cent years,mainly from the aspects of cell death,inflammatory signal transduction and epithelial-mesenchymal transition induced by ER stress through three classic signaling pathways,aiming to provide new ideas and directions for the prevention and treatment of peritoneal dialysis-related peritonitis and peri-toneal fibrosis.
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