sdEEG联合血清谷氨酰胺、IGF-1检测对儿童癫痫的诊断价值
Diagnostic Value of sdEEG Combined with Serum Glutamine and IGF-1 Detection in Children with Epilepsy
石红蕾 1汪学静 1齐凤芹 1钟芳芳1
作者信息
- 1. 252600 山东 临清,聊城市第二人民医院儿科
- 折叠
摘要
目的 分析剥夺睡眠脑电图(sdEEG)联合血清谷氨酰胺、胰岛素样生长因子-1(IGF-1)在儿童癫痫诊断中的应用价值.方法 选取2020 年3 月—2022 年 3 月收治的 86 例疑似癫痫患儿作为观察对象,均进行sdEEG检查.分析sdEEG对癫痫检出情况,比较sdEEG对不同年龄段患儿癫痫样放电的检出率及出现癫痫样放电时间,同时比较癫痫与非癫痫患儿血清谷氨酰胺、IGF-1 水平.采用受试者工作特征曲线评估sdEEG、血清谷氨酰胺、IGF-1 对儿童癫痫的诊断价值.结果 86 例疑似癫痫患儿确诊癫痫 74 例(86.05%).sdEEG诊断癫痫 66 例,非癫痫 20 例,检出率为76.74%.sdEEG对1～3 岁患儿癫痫样放电的检出率高于4～7 岁和＞7 岁患儿(P＜0.05);患儿睡眠期癫痫样放电占比高于清醒期和思睡期(P＜0.01).癫痫患儿血清谷氨酰胺、IGF-1 水平低于非癫痫患儿(P＜0.01).sdEEG、血清谷氨酰胺和IGF-1 诊断儿童癫痫的曲线下面积(AUC)分别为 0.849、0.740、0.804,三者联合检测AUC为0.735.结论 sdEEG适用于各年龄阶段癫痫患儿的检查,sdEEG、血清谷氨酰胺和IGF-1 对儿童癫痫均具有较高的诊断价值.
Abstract
Objective To analyze the application value of sleep-deprivation electroencephalogram(sdEEG)com-bined with serum glutamine and insulin-like growth factor-1(IGF-1)in children with epilepsy.Methods A total of 86 chil-dren with suspected epilepsy admitted to hospital from March 2020 to March 2022 were selected as observation subjects,all of whom underwent sdEEG examination.The detection of epilepsy by sdEEG was analyzed,the detection rate of epileptic dis-charge and the time of epileptic discharge by sdEEG in children of different ages were compared,and the serum glutamine and IGF-1 levels were compared between epileptic and non-epileptic children.The diagnostic value of sdEEG combined with serum glutamine and IGF-1 in children with epilepsy was evaluated by receiver operating characteristic(ROC)curve.Results Of the 86 children with suspected epilepsy,74(86.05%)were diagnosed with epilepsy.Sixty-six patients with epilepsy and20 patients without epilepsy were diagnosed by sdEEG,and the detection rate was 76.74%.The detection rate of epileptic dis-charge in children aged 1 to 3 years was the highest by sdEEG,which was significantly higher than that in children aged 4 to 7 years and＞7 years(P＜0.05).The proportion of epileptic discharge in sleep period was significantly higher than that in awake period and sleepiness period by sdEEG(P＜0.01).Serum levels of glutamine and IGF-1 in epileptic children were significantly lower than those in non-epileptic children(P＜0.01).The area under the ROC curve(AUC)of sdEEG,serum glutamine and IGF-1 in the diagnosis of childhood epilepsy were 0.849,0.740 and 0.804,respectively,and the AUC of the combined detection of the three was 0.735.Conclusion sdEEG is appropriate for the detection of epilepsy in children of all ages.sdEEG,serum glutamine and IGF-1 are of high value in the diagnosis of epilepsy in children.
关键词
癫痫/儿童/剥夺睡眠脑电图/睡眠期/胰岛素样生长因子-1/谷氨酰胺/受试者工作特征曲线/诊断Key words
Epilepsy/Child/Sleep-deprivation electroencephalography/Sleep stage/Insulin-like growth factor-1/Glutamine/Receiver operating characteristic curve/Diagnosis引用本文复制引用
基金项目
山东省中医药科技项目(Q-2022040)
出版年
2023
国家科技期刊平台
NSTL
万方数据