地屈孕酮辅助宫腔镜子宫内膜息肉切除术治疗对患者子宫内膜厚度、VEGF水平及复发率的影响
Effects of Dydrogesterone Assisted Hysteroscopic Transcervical Resection of Polyps on Endometrial Thickness,VEGF Level and Recurrence Rate after
李璐 1朱世丽 1纪芬1
作者信息
- 1. 230092 合肥,合肥市第一人民医院滨湖院区妇产科
- 折叠
摘要
目的 探讨地屈孕酮辅助宫腔镜子宫内膜息肉切除术(TCRP)治疗对患者子宫内膜厚度、血管内皮生长因子(VEGF)水平及复发率的影响.方法 选取2020 年6 月—2022 年3 月治疗的124 例子宫内膜息肉作为研究对象,按照治疗方式的不同分为观察组(地屈孕酮辅助TCRP治疗)66 例与对照组(单一TCRP治疗)58 例.分析2 组临床疗效、子宫内膜厚度、VEGF水平、复发率、月经情况,以及观察组不良反应发生情况.结果 观察组治疗后临床总有效率为95.45%(63/66)高于对照组的75.86%(44/58)(P＜0.01).治疗3 个月后,观察组子宫内膜厚度与VEGF水平均低于对照组(P＜0.05).治疗1 年后,观察组月经情况改善程度优于对照组(P＜0.05).观察组治疗后第 9、12 个月复发率均低于对照组(P＜0.05).治疗过程中,观察组无恶心、乳房疼痛、腹痛、阴道出血等不良反应发生.结论 地屈孕酮辅助TCRP治疗方案对子宫内膜息肉患者疗效确切,可显著改善子宫内膜厚度以及VEGF水平,有效降低复发率、改善月经情况,且安全可靠.
Abstract
Objective To investigate the effects of Dydrogesterone assisted hysteroscopic transcervical resection of polyps(TCRP)on endometrial thickness,vascular endothelial growth factor(VEGF)level and recurrence rate.Methods A total of 124 cases of intrauterine polyps treated from June 2020 to March 2022 were selected as the research subjects,and were divided into observation group(Dydrogesterone-assisted TCRP treatment,n =66)and control group(single TCRP treat-ment,n =58)according to different treatment methods.The clinical efficacy,endometrial thickness,VEGF level,recurrence rate,menstruation of the two groups,and the occurrence of adverse reactions in the observation group were analyzed.Results The total effective rate of the observation group was 95.45%(63/66),which was higher than that of the control group[75.86%(44/58)](P＜0.01).At 3 months after treatment,endometrial thickness and VEGF levels in the observation group were lower than those in the control group(P＜0.05).At 1 year after treatment,the improvement of menstruation in observation group was better than that in control group(P＜0.05).The recurrence rate at 9 and 12 months after treatment in the observation group was lower than that in the control group(P＜0.05).During the treatment,no adverse reactions such as nausea,breast pain,abdominal pain and vaginal bleeding occurred in the observation group.Conclusion Dydrogesterone-assisted TCRP therapy is effective in patients with endometrial polyps,which can significantly improve endometrial thickness and VEGF levels,effectively reduce the recurrence rate,improve menstruation,and is safe and reliable.
关键词
子宫内膜息肉/地屈孕酮/子宫内膜息肉切除术/宫腔镜/子宫内膜厚度/血管内皮生长因子/复发/月经周期Key words
Endometrial polyps/Dydrogesterone/Transcervical resection of polyps/Hysteroscopes/Endometrial thickness/Vascular endothelial growth factor/Recurrence/Menstrual cycle引用本文复制引用
基金项目
安徽省自然科学基金(20080185QH1358)
出版年
2023
国家科技期刊平台
NSTL
万方数据