大柴胡汤联合生长抑素治疗急性胰腺炎的效果及对血清炎性指标、生化指标的影响
Effect of Dachaihu Decoction Combined with Somatostatin on Acute Pan-creatitis and Its Impact on Serum Inflammatory and Biochemical Indicators
杨勐 1沈浩 1赵飞1
作者信息
- 1. 234000 安徽 宿州,宿州市第一人民医院消化内科
- 折叠
摘要
目的 探讨大柴胡汤联合生长抑素治疗急性胰腺炎(AP)患者效果及对血清炎性指标、生化指标等的影响.方法 选取2019 年1 月—2022 年12 月收治的AP 148 例,按照治疗方法不同将其分为观察组和对照组2 组各74 例,观察组采用大柴胡汤联合生长抑素治疗,对照组采用生长抑素治疗.比较2 组治疗后临床效果,治疗前后中医症状积分、血清炎性指标[降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、生化指标(血钙、血淀粉酶、尿淀粉酶)及外周血单核细胞 p38 丝裂原活化蛋白激酶(p38MAPK)、磷酸化-丝裂原活化蛋白激酶 p38 抗体(p-p38MAPK),以及治疗期间不良反应.结果 治疗后,观察组总有效率 91.89%(68/74)高于对照组 77.03%(57/74)(P＜0.05).治疗后,2 组各中医症状积分、血清炎性指标、血淀粉酶、尿淀粉酶及外周血单核细胞 p38MAPK、p-p38MAPK均低于治疗前;观察组血钙高于治疗前和对照组,各中医症状积分、血清炎性指标、血淀粉酶、尿淀粉酶及外周血单核细胞p38MAPK、p-p38MAPK低于对照组(P＜0.01).治疗期间,2 组不良反应总发生率比较差异无统计学意义(P＞0.05).结论 大柴胡汤联合生长抑素治疗AP患者效果显著,可减轻炎症反应,调节消化酶水平,下调外周血单核细胞p38MAPK、p-p38MAPK表达水平,进而改善临床症状.
Abstract
Objective To investigate the effect of Dachaihu decoction combined with somatostatin in the treatment of acute pancreatitis(AP)and its effects on serum Serum inflammatory and biochemical indicators.Methods A total of 148 patients with AP treated from January 2019 to December 2022 were selected and divided into observation group(n =74)and control group(n =74)according to different treatment methods.The observation group was treated with Dachaihu decoction combined with somatostatin,while the control group was treated with somatostatin.The clinical effect after treatment was com-pared between the two groups.TCM symptom score,serum inflammatory indexes[procalcitonin(PCT),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],biochemical indexes(serum calcium,serum amylase,urine amylase)and ex-pression levels of p38 mitogen-activated protein kinase(p38MAPK)and phosphoryl-mitogen-activated protein kinase p38 anti-body(p-p38MAPK)in peripheral blood monocytes before and after treatment and adverse reactions during treatment were compared between the two groups.Results After treatment,the total effective rate of observation group was 91.89%(68/74),which was higher than that of control group[77.03%(57/74)](P＜0.05).After treatment,the TCM symptom score,serum inflammatory indexes,blood amylase,urine amylase and p38MAPK and p-p38MAPK of peripheral blood mononuclear cells in the two groups were lower than those before treatment.The blood calcium of the observation group was higher than that before treatment,and that of the control group,and the TCM symptom score,serum inflammatory indexes,blood amylase,urine amylase and p38MAPK and P-P38MAPK of peripheral blood mononuclear cells were lower than those of the control group(P＜0.01).There was no significant difference in total incidence of adverse reactions during treatment between the two groups(P＞0.05).Conclusion Dachaihu decoction combined with somatostatin has a significant effect in the treatment of AP patients,which can reduce inflammatory reactions,regulate digestive enzyme levels,down-regulate p38MAPK and p-p38MAPK expression levels in peripheral blood mononuclear cells,and hence improve clinical symptoms.
关键词
胰腺炎/大柴胡汤/生长抑素/降钙素原/肿瘤坏死因子-α/白细胞介素-6/钙/p38丝裂原活化蛋白激酶Key words
Pancreatitis/Dachaihu decoction/Somatostatin/Procalcitonin/Tumor necrosis factor-α/Interleukin-6/Calcium/p38 mitogen-activated protein kinases引用本文复制引用
基金项目
安徽省自然科学基金(2020122QH0173)
出版年
2023
国家科技期刊平台
NSTL
万方数据