摘要
目的 探讨亮菌口服溶液对肝癌术后患者免疫功能、肝功能及炎性因子的影响.方法 选取2019 年2月—2020 年3 月收治的原发性肝癌94 例,根据术后应用药物的不同均分为观察组和对照组.对照组在术后常规抗感染、护肝基础上加用恩替卡韦治疗,研究组在对照组基础上联合亮菌口服溶液治疗.比较 2 组临床疗效,治疗前后免疫功能指标、炎性因子、肝功能指标变化,治疗期间不良反应及无进展生存期(PFS)、总生存时间(OS).结果 研究组治疗总有效率为95.74%(45/47)明显高于对照组的 82.98%(39/47)(P＜0.05).治疗后 2 组CD3 +、CD4 +、CD8 +、CD4 +/CD8 +及白蛋白水平均明显升高,且研究组较对照组明显升高(P＜0.05,P＜0.01).治疗后2 组C反应蛋白、白细胞介素-1、肿瘤坏死因子-α、白细胞介素-6 及总胆红素、丙氨酸转氨酶、天冬氨酸转氨酶水平均降低,且研究组较对照组降低明显(P＜0.05,P＜0.01).研究组不良反应总发生率明显低于对照组(P＜0.05).研究组PFS和OS均长于对照组(P＜0.01).结论 亮菌口服溶液可调节肝癌术后患者免疫功能,抗炎、抗肿瘤效果显著,并可有效促进患者肝功能恢复、延长患者生存期.
Abstract
Objective To investigate the effects of Armillariella oral solution on immune function,liver function and inflammatory factors in patients with liver cancer after operation.Methods A total of 94 cases of primary liver cancer treated from February 2019 to March 2020 were selected and divided into research group and control group according to different post-operative drugs.The control group was treated with Entecavir on the basis of routine anti-infection and liver protection after op-eration,and the research group was treated with Armillariella oral solution on the basis of control group.The clinical efficacy,changes of immune function indexes,inflammatory factors,liver function indexes before and after treatment,adverse reac-tions,progression-free survival(PFS)and overall survival(OS)during treatment were compared between the two groups.Results The total effective rate of the research group was 95.74%(45/47),which was significantly higher than that of the control group[82.98%(39/47)](P＜0.05).After treatment,the levels of CD3 +,CD4 +,CD8 +,CD4 +/CD8 + and albumin in the two groups were significantly increased,which were significantly higher in the research group than in the control group(P＜0.05,P＜0.01).After treatment,the levels of C reactive protein,interleukin-1,tumor necrosis factor-α,inter-leukin-6,total bilirubin,alanine aminotransferase and aspartate aminotransferase in the two groups were decreased,and the levels in the research group were significantly lower than those in the control group(P＜0.05,P＜0.01).The total incidence of adverse reactions in the research group was significantly lower than that in control group(P＜0.05).The PFS and OS of the research group were longer than those of the control group(P＜0.01).Conclusion Armillariella oral solution can regu-late the immune function of patients with liver cancer after operation,and has significant anti-inflammatory and anti-tumor effects,which can effectively promote the recovery of liver function and prolong the survival of patients.
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