Objective To analyze the extrarenal multi-system manifestations and early causes of misdiagnosis of chro-nic renal failure(CRF).Methods The clinical data of 14 patients with misdiagnosed CRF admitted from July 2021 to Feb-ruary 2023 were retrospectively analyzed.Results Four cases were misdiagnosed as pruritus due to main symptoms,inclu-ding dry,dull skin,pruritus and withered hair.Three cases were misdiagnosed as anemia due to fatigue,dizziness,palpita-tion and pale complexion as well as a decrease in hemoglobin.Three cases were misdiagnosed as primary hypertension due to varying degrees of headache,dizziness,blurred vision and elevated blood pressure,and 4 cases were misdiagnosed as chronic gastritis due to different degrees of loss of appetite,nausea and vomiting,and abdominal discomfort,combined with the results of fiberscope.The condition of 14 cases did not improve significantly after targeted treatment.After consultation,urine rou-tine,kidney function and kidney B-ultrasound were performed,and CRF was confirmed after comprehensive analysis of the condition.The duration of misdiagnosis was 1-3 months.After diagnosis,blood creatinine and urea levels were decreased in 14 cases after treatment for primary disease,inducement treatment,and diet therapy,and metabolic acidosis,electrolyte dis-turbance and anemia were corrected.The condition was stable at 1-year follow-up.Conclusion The early symptoms of CRF are often atypical,which can easily lead to misdiagnosis.In clinical practice,patients with extrarenal system symptoms at ini-tial visit should be comprehensively analyzed,and timely urine routine,renal function and renal imaging examinations can ef-fectively avoid misdiagnosis of this disease.