Objective To investigate the causes and preventive measures of misdiagnosis of glioma as acute dissemi-nated encephalomyelitis(ADEM)and acute cerebral infarction(ACI).Methods The clinical data of 16 cases with initial misdiagnosis of glioma treated from April 2020 to October 2022 were retrospectively analyzed.Results All patients presented with sudden headache,dizziness,nausea and vomiting.There were 10 cases of sensory and motor disturbance,fatigue of the affected limbs,and 9 cases of apathy.Head MRI examination in 9 cases showed slightly longer T2 and T1 signal shadows with uniform signal density of the lesion.Seven cases showed long T2 and equally low T1 signal shadow in the right basal ganglia area,and FLAIR showed high signal.Sixteen cases were initially misdiagnosed as ADEM(n =9)and ACI(n =7).The cor-responding treatment was not effective and the duration of misdiagnosis was 2-4 months.All patients were diagnosed with glio-ma(astrocytoma)by head puncture and histopathology.Nine patients underwent conformal intensity-modulated radiotherapy(IMRT)and concurrent chemotherapy,and 7 patients received only IMRT and concurrent chemotherapy.After 1 year of follow-up,3 cases were lost to follow-up,2 cases died and 11 cases were stable.Conclusion The clinical manifestations of brain glioma are varied,which is,therefore,more likely to be misdiagnosed.For similar patients in clinical settings,attention should be paid to dynamic tracking of the condition,coupled with brain histopathological examination when necessary,for ear-ly diagnosis and treatment.
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