Objective To investigate the ultrasonographic characteristics of intraductal papilloma(IDP)of the breast and the causes of misdiagnosis.Methods The clinical data of 19 patients with IDP who underwent surgical treatment from March 2020 to March 2023 were retrospectively analyzed.Among them,11 cases were misdiagnosed by ultrasound and 8 cases were confirmed.Results Among the 19 patients,3 presented with simple nipple discharge,13 with breast mass,and 3 with nipple discharge combined with breast mass.Ductal dilation with intraductal solid papillary type was not misdiagnosed in 5 ca-ses.Of the 9 cases with ductal dilation and solid nodules at distal interruption,3 were not misdiagnosed,6 were misdiag-nosed;3 cases were misdiagnosed as breast cancer,including 2 as simple ductal dilation,and 1 as fibroadenoma.One case of cystic nodular type was misdiagnosed as breast cancer.There were 4 cases of parenchymatous nodular type,including 3 cases misdiagnosed as fibroadenoma and 1 case as breast cancer.All the 19 cases had IDP which was confirmed by pathological ex-amination and followed up for 1 year after operation.No recurrence was found and the prognosis was good.Conclusion Early IDP ultrasonography and clinical manifestations are not typical,which is more likely to cause misdiagnosis.Clinicians should be familiar with ultrasound manifestations of IDP,carefully observe the tumor margin and envelope,and if necessary,locally expand the observation,perform color Doppler flow imaging examination,and carefully differentiate diagnosis,combined with clinical practice,to avoid early ultrasound misdiagnosis to a certain extent.