Predictive Efficacy of Serum Galectin-9 and CXCL10 for Chemotherapy-related Cardiotoxicity in Elderly Patients with Colon Cancer and Coronary Heart Disease
Predictive Efficacy of Serum Galectin-9 and CXCL10 for Chemotherapy-related Cardiotoxicity in Elderly Patients with Colon Cancer and Coronary Heart Disease
Objective To explore the predictive efficacy of serum Galectin-9 and CXC chemokine ligand 10(CXCL10)in chemotherapy-related cardiotoxicity in elderly colon cancer patients with coronary heart disease(CHD).Meth-ods A total of 104 elderly patients with colon cancer and CHD admitted from January 2020 to January 2023 were selected as the research subjects.According to occurrence of chemotherapy-related cardiotoxic events,they were divided into the non-cardiotoxicity group(n =76)and the cardiotoxicity group(n =28).Serum Galectin-9 and CXCL10 levels were compared be-tween the two groups,and the predictive value of serum Galectin-9 and CXCL10 in chemotherapy-related cardiotoxicity in eld-erly patients with colon cancer and CHD was evaluated by receiver operating characteristic curve.Multivariate Logistic regres-sion analysis was used to investigate the influencing factors of chemotherapy-related cardiotoxicity in elderly patients with colon cancer and CHD.Results The levels of Galectin-9 and CXCL10 in the cardiotoxicity group were higher than those in the non-cardiotoxicity group(P＜0.01).The area under the curve(AUC)of serum Galectin-9 and CXCL10 was 0.805 and 0.739 respectively,the specificity was 64.76%and 56.87%respectively,and the sensitivity of both was 91.45%.The AUC of combined detection in prediction was 0.906,the specificity was 86.97%,and the sensitivity was 87.47%.Left ventricular ejection fraction≤51.74%,serum Galectin-9≥10.81 μg/L,and serum CXCL10≥127.24 pg/mL were independent risk factors for chemotherapy-related cardiotoxicity in elderly patients with colon cancer and CHD(P＜0.01).Conclusion In-creased serum Galectin-9 and CXCL10 levels are closely related to chemotherapy-related cardiotoxicity in elderly patients with colon cancer and CHD,and can be used as biological indicators to evaluate chemotherapy-related cardiotoxicity in patients,and the combined prediction of the two is more effective.
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