Objective To explore the diagnostic value of prostate imaging reporting and data systemversion 2(PI-RADS v2)combined with apparent diffusion coefficient(ADC)in prostate cancer.Methods A total of 80 patients with prostate disease who were treated in our hospital from July 2017 to July 2021 were included in this study.According to the re-sults of prostate biopsy,all patients were divided into prostate cancer group(n =51)and non-prostate cancer group(n =29).All patients underwent plain MRI in stable condition,for measurement of ADC values,and scoring of PI-RADS v2.PI-RADS v2 scores and ADC of the two groups were compared,and receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of PI-RADS v2 scores combined with ADC values for prostate cancer.Results PI-RADS v2 scores were higher in prostate cancer group than in non-prostate cancer group,while ADC value was significantly lower than that in non-prostate cancer group(P<0.01).The sensitivity of PI-RADS v2 scores(with the threshold of 4 points)in the diagnosis of prostate cancer was 82.35%,the specificity was 75.86%,the accuracy was 80.00%,and the area under the ROC curve(AUC)was 0.829.The sensitivity of ADC value(with the threshold of 850×10-6 mm2/s)in the diagnosis of prostate canc-er was78.43%,the specificity was79.31%,the accuracy was 78.75%,and the AUC was 0.816;the sensitivity of com-bined detection in the diagnosis of prostate cancer was 92.16%,the specificity was 89.66%,the accuracy was 91.23%,and the AUC was 0.868.The AUC of combined diagnosis was significantly larger than that of PI-RADS v2 scores and ADC alone.Conclusion The PI-RADS v2 scores combined with ADC values has good diagnostic value for prostate cancer and is more ac-curate than a single detection.