摘要
目的 分析芪冬颐心口服液治疗急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)术后的临床疗效.方法 选取2021 年10 月—2022 年12 月接受PCI术治疗的80 例AMI,按随机数字表法分为对照组和观察组,每组40例.对照组给予西酞普兰治疗,观察组给予芪冬颐心口服液联合西酞普兰治疗.分析2 组临床疗效、心功能指标、心脏微血管功能[血管细胞间黏附分子-1(VCAM-1)、内皮素-1(ET-1)、细胞间黏附分子-1(ICAM-1)、一氧化氮(NO)]、血液流变学指标[纤维蛋白原(FIB)、全血低切黏度(NBL)、血浆黏度(PV)、全血高切黏度(NBH)]、匹兹堡睡眠质量指数(PSQI)评分、汉密尔顿焦虑量表(HAMA)评分以及主要心血管不良事件(MACE)发生率.结果 观察组临床总有效率92.50%(37/40)高于对照组75.00%(30/40)(P＜0.05).治疗后,观察组左心室舒张末期内径、左心室收缩末期内径、NBH、PV、FIB、NBL、HAMA评分、PSQI评分及血清VCAM-1、ET-1、ICAM-1 低于对照组,左心室射血分数及血清NO高于对照组(P＜0.05).观察组MACE发生率低于对照组(P＜0.05).结论 芪冬颐心口服液治疗AMI患者PCI术后疗效确切,可改善患者心脏微血管功能及焦虑状态,并提高睡眠质量.
Abstract
Objective To analyze the clinical effect of Qidong Yixin Koufuye on patients with acute myocardial in-farction(AMI)after percutaneous coronary intervention(PCI).Methods Eighty patients with AMI who received PCI from October 2021 to December 2022 were selected and divided into control group(n =40)and observation group(n =40)ac-cording to random number table method.The control group was given Citalopram,and the observation group was given Qidong Yixin Koufuye combined with Citalopram.Clinical efficacy,cardiac function indexes,cardiac microvascular function[vascu-lar intercellular adhesion molecule-1(VCAM-1),endothelin-1(ET-1),intercellular adhesion molecule-1(ICAM-1),nitric oxide(NO)],hemorheological indexes[fibrinogen(FIB),whole-blood low shear viscosity(NBL),plasma viscosity(PV),whole-blood high shear viscosity(NBH)],Pittsburgh Sleep Quality Index(PSQI)score,Hamilton Anxiety Scale(HAMA)score,and incidence of major cardiovascular adverse events(MACE)were compared between the two groups.Results The total effective rate of observation group was higher than that of control group[92.50%(37/40)vs.75.00%(30/40)](P＜0.05).After treatment,left ventricular end-diastolic diameter,left ventricular end-systolic diameter,NBH,PV,FIB,NBL,HAMA score,PSQI score and serum VCAM-1,ET-1 and ICAM-1 in the observation group were lower than those in the control group,while left ventricular ejection fraction and serum NO were higher than those in control group(P＜0.05).The incidence of MACE in observation group was lower than that in control group(P＜0.05).Conclusion Qidong Yixin Kou-fuye has definite curative effect on AMI patients after PCI,which can improve cardiac microvascular function,anxiety state and sleep quality.
基金项目
河北省2023年度医学科学研究课题(20232064)
张家口市重点研发计划项目(2221060D)
维普
万方数据