Objective To investigate the clinical characteristics,causes of misdiagnosis and preventive measures of osteoporotic vertebral compression fracture(OVCF).Methods The clinical data of 14 patients with OVCF who had been misdiagnosed from February 2022 to April 2023 were retrospectively analyzed.Results In this group,the main complaint of 7 patients was hypochondriac pain,and the main complaint of 7 patients was digestive symptoms such as belching,loss of ap-petite,abdominal pain and abdominal distension.There were 7 patients with low back percussion pain,8 patients with abdom-inal distension,percussive sound,and weakened intestinal sound.X-ray examination found only thoracolumbar scoliosis in 7 patients.The initial diagnosis was misdiagnosis as gastrointestinal neurosis and intercostal neuralgia in 7 cases respectively.The corresponding treatment was not effective and they were transferred to our hospital.The misdiagnosis lasted 12-20 d.OVCF was confirmed by medical history and MRI of thoracolumbar vertebrae.After drug treatment with osteoporosis-related drugs and posterior percutaneous thoracolumbar kyphoplasty,the symptoms were completely relieved or disappeared.Vertebral healing was reviewed at 6 months after surgery,and spinal movement was basically normal.Conclusion OVCF is prone to misdiagnosis.When receiving patients with no obvious history of trauma and presenting them with symptoms of hypochondriac pain or digestive system,careful physical examination should be conducted,detailed medical history and pain characteristics should be inquired,X-ray or MRI examination should be performed as soon as possible,and attention should be paid not to be interfered with the diagnosis of negative fracture by early X-ray examination,so as to reduce OVCF.