摘要
目的 探究阴道内镜联合宫颈环形电切术(LEEP)在宫颈上皮内瘤变(CIN)治疗中的应用效果.方法 选取2020 年3 月—2022 年3 月160 例CIN为研究对象,按照随机数字表法分为2 组,每组80 例.对照组采用宫颈激光烧灼术,研究组采用阴道内镜联合LEEP.比较2 组围术期指标、临床疗效、肿瘤标志物[糖类抗原125(CA125)、糖类抗原153(CA153)]、炎性-应激因子[白细胞介素-6(IL-6)、C 反应蛋白(CRP)、过氧化氢酶(CAT)、丙二醛(MDA)]、疾病进展相关因子[生存素(Survivin)、DNA甲基转移酶1(DNMT1)、DNA甲基转移酶3a(DNMT3a)]、并发症及复发情况.结果 研究组手术时间、住院时间、术后出血时间、创面愈合时间短于对照组,出血量少于对照组(P<0.01).研究组临床总有效率96.25%(77/80)高于对照组81.25%(65/80)(P<0.01).研究组术后第3、7 天血清CA125、CA153、IL-6、CRP、CAT、MDA、Survivin、DNMT1、DNMT3a水平均低于对照组(P<0.05).研究组并发症发生率及复发率均低于对照组(P<0.05).结论 阴道内镜联合LEEP治疗CIN患者临床效果确切,不仅能降低血清肿瘤标志物、炎性-应激因子、疾病进展相关因子表达,还可降低患者并发症发生率及复发率.
Abstract
Objective To explore the application effect of colpoendoscopy combined with cervical loop electrosurgical excision procedure(LEEP)in the treatment of cervical precancerous lesions.Methods A total of 160 patients with cervical precancerous lesions(cervical intraepithelial neoplasia)from March 2020 to March 2022 were selected as the research sub-jects,and were divided into two groups according to random number table method,with 80 cases in each group.The control group was treated with laser cauterization of cervix,and the research group was treated with colposcopy combined with LEEP.Perioperative indexes,clinical efficacy,tumor markers[carbohydrate antigen 125(CA125),carbohydrate antigen 153(CA153)],inflammatory stress factors[interleukin-6(IL-6),C-reactive protein(CRP),catalase(CAT),malonaldehyde(MDA)],and disease-progression related factors[Survivin,DNA methyltransferase 1(DNMT1),DNA methyltransferase 3a(DNMT3a)],complications and recurrence were compared between the two groups.Results The duration of operation,length of hospitalization,postoperative bleeding time and wound healing time of the research group were shorter than those of the control group,and the amount of bleeding was less than that of the control group(P<0.01).The total effective rate of the research group was 96.25%(77/80),which was higher than that of the control group[81.25%(65/80)](P<0.01).Serum levels of CA125,CA153,IL-6,CRP,CAT,MDA,Survivin,DNMT1 and DNMT3a in the research group were lower than those in the control group at 3 and 7 d after surgery(P<0.05).The complication rate and recurrence rate of the re-search group were lower than those of the control group(P<0.05).Conclusion In the treatment of patients with cervical precancerous lesions,colpoendoscopy combined with LEEP has definite clinical effect,which can not only reduce the expres-sion of serum tumor markers,inflammatory stress factors,and factors related to disease progression,but also reduce the inci-dence of complications and recurrence of patients.
基金项目
秦皇岛市重点研发计划科技支撑项目(202301A201)
维普
万方数据