Objective To explore the relationship between endoplasmic reticulum stress signaling pathway protein ki-nase R-like endoplasmic reticulum kinase(PERK)and atherosclerotic(AS)plaque stability.Methods A total of 150 pa-tients with AS plaque admitted from February 2021 to February 2023 were selected as the observation group,and another 150 healthy subjects undergoing physical examination were selected as the control group.The levels of PERK signaling pathway-related factors were compared between the two groups,and the effects of PERK signaling pathway-related factors on the risk of AS plaques were analyzed.The clinical data of patients with different plaque properties and the factors related to PERK signa-ling pathway were compared to analyze the correlation between PERK signaling pathway-related factors and lipid indexes and their effects on the stability of AS plaques.The receiver operating characteristic(ROC)curve was used to evaluate the predic-tive value of PERK signaling pathway-related factors for the stability of AS plaques.Results The serum levels of PERK,ac-tivated transcription factor 4(ATF4)and C/EBP homologous protein(CHOP)in observation group were higher than those in control group(P<0.01).When serum PERK,CHOP and ATF4 levels were high,the risk of AS plaque was 2.947 times,1.586 times and 1.727 times higher than that of low levels,respectively.Total cholesterol(TC),low-density lipoprotein cho-lesterol(LDL-C),triglyceride(TG),PERK,CHOP and ATF4 were lower in patients with stable plaque than those with un-stable plaque,while high-density lipoprotein cholesterol(HDL-C)was higher than that with unstable plaque(P<0.01).PERK,CHOP and ATF4 were positively correlated with TC,LDL-C and TG,and negatively correlated with HDL-C in AS plaque patients(P<0.01).PERK,CHOP and ATF4 were the influential factors of AS plaque instability(P<0.01).The area under the ROC curve of combined detection of PERK,CHOP and ATF4 in predicting AS instability was 0.929,which was significantly higher than that predicted by each factor alone(P<0.05,P<0.01).Conclusion PERK signaling path-way is involved in the development of AS plaques,which is significantly correlated with lipid markers TC,LDL-C,TG and HDL-C.Detection of the factors related to PERK signaling pathway is helpful for clinical prediction of AS plaque properties.
维普
万方数据