Objective To investigate the predictive efficacy of serum heat shock protein 70(HSP70)and soluble CD74(sCD74)on the risk of acute exacerbation in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 103 patients with COPD treated from January to December 2022 were selected,and 90 healthy subjects who under-went physical examination during the same period were selected as the control group.According to the number of acute exacer-bations within 1 year before admission,patients were divided into low-risk acute exacerbation group(n =48)and high-risk a-cute exacerbation group(n =55).The expression levels of serum HSP70 and serum sCD74 were detected by enzyme-related immunosorbent assay.The predictive value of serum HSP70 and sCD74 for the risk of acute exacerbation in COPD patients was evaluated by receiver operating characteristic(ROC)curve.Multivariate Logistic regression was used to analyze the fac-tors affecting the risk of acute exacerbation in COPD patients.Results The serum HSP70 level in the observation group was lower than that in the control group,while the serum sCD74 level was higher than that in the control group(P<0.01).Ser-um HSP70 level in low-risk acute exacerbation group was higher than that in high-risk acute exacerbation group,while serum sCD74 level was lower than that in high-risk acute exacerbation group(P<0.01).The area under the ROC curve of com-bined detection of serum HSP70 and sCD74 in predicting the risk of acute exacerbation in COPD patients was greater than that of two factors alone in prediction.HSP70<1.16 μg/L and sCD74≥75.56 ng/mL were risk factors for acute exacerbation in COPD patients(P<0.01).Conclusion Low levels of HSP70 and high levels of sCD74 can increase the risk of acute exac-erbation of COPD,and the combined detection of HSP70 and sCD74 has high efficacy in predicting the risk of acute exacerba-tion of COPD.
维普
万方数据