临床误诊误治2023,Vol.36Issue(12) :146-149,154.DOI:10.3969/j.issn.1002-3429.2023.12.029

Th1/Th2细胞因子在早产儿呼吸窘迫综合征发病中的研究进展

Research Progress on the Th1/Th2 Cytokines in the Pathogenesis of Respir-atory Distress Syndrome in Premature Infants

杨小兰 谢美玲 廖晓兰 刘李 刘燕茹
临床误诊误治2023,Vol.36Issue(12) :146-149,154.DOI:10.3969/j.issn.1002-3429.2023.12.029

Th1/Th2细胞因子在早产儿呼吸窘迫综合征发病中的研究进展

Research Progress on the Th1/Th2 Cytokines in the Pathogenesis of Respir-atory Distress Syndrome in Premature Infants

杨小兰 1谢美玲 1廖晓兰 2刘李 3刘燕茹3
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作者信息

  • 1. 636000 四川 巴中,巴中市中医医院(巴州区人民医院)儿科
  • 2. 635099 四川 达州,达州市通川区人民医院儿科
  • 3. 610000 成都,成都市妇女儿童中心医院儿科
  • 折叠

摘要

呼吸窘迫综合征(RDS)好发于早产儿,发病主要与Th1/Th2 细胞因子失衡有关,以Th1 型细胞因子占优势地位,但Th1/Th2 细胞因子失衡参与RDS发生发展的具体机制尚未明确,所以明确RDS的发病机制,采取合理有效的治疗措施是降低早产RDS患儿病死率的关键.故本文通过查阅国内外相关研究资料,着重阐述Th1/Th2 细胞因子在早产RDS患儿中的表达及其作用机制,以期为本病的治疗提供新思路.

Abstract

Respiratory distress syndrome(RDS)often strike premature infants,and its pathogenesis is mainly related to Th1/Th2 cytokine imbalance,especially the predominant Th1 cytokine.However,the specific mechanism of Th1/Th2 cyto-kine imbalance participating in the occurrence and development of RDS has not yet been well understood.Clarifying the patho-genesis of RDS and taking reasonable and effective treatment measures is the key to reducing the mortality of premature chil-dren with RDS.Therefore,by referring to relevant research data at home and abroad,this study focused on the expression of Th1/Th2 cytokines in premature children with RDS and its mechanism of action,in order to provide new ideas for the treat-ment of this disease.

关键词

呼吸窘迫综合征/婴儿,早产/Th1细胞因子/肿瘤坏死因子-α/Th2细胞因子/白细胞介素-4/肺表面活性物质/综述

Key words

Respiratory distress syndrome/Infant,premature/Th1 cytokines/Tumor necrosis factor-α/Th2 cyto-kines/Interleukin-4/Pulmonary surfactant/Review

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基金项目

四川省卫生和计划生育委员会科研课题普及应用项目(18PJ049)

出版年

2023
临床误诊误治
解放军白求恩国际和平医院

临床误诊误治

CSTPCD
影响因子:0.914
ISSN:1002-3429
参考文献量12
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