Objective To analyze the interaction between serum relaxin(RLX)in the third trimester,delivery mode and pelvic floor dysfunction(PFD)in primipara.Methods A total of 203 primipara treated in our hospital from March 2019 to December 2022 were selected and divided into PFD group(n =43)and non-PFD group(n =160)according to presence of PFD in 42 d postpartum.The baseline data of the two groups and serum RLX in the third trimester were compared,and the re-lated risk factors of PFD in the early postpartum period were analyzed by Logistic regression analysis.Interaction coefficient γ and odds ratio(OR)were used to analyze the interaction between serum RLX in the third trimester,mode of delivery and PFD of primipara in the early postpartum period.Receiver operating characteristic(ROC)curve was used to analyze the value of serum RLX and mode of delivery alone and in combination in prediction of PFD of primipara in the early postpartum period.Results The proportion of natural delivery in PFD group was higher than that in non-PFD group(P＜0.05).The serum RLX in the PFD group was(657.33±178.56)ng/L,which was higher than that in the non-PFD group[(460.81±142.35)ng/L](P＜0.05).Logistic regression analysis showed that natural delivery and serum RLX were the risk factors for PFD in the early postpartum period(P＜0.01).The serum RLX of puerpera undergoing natural delivery was higher than that of primipara undergoing cesarean section(P＜0.05).OR caused by serum RLX alone in the third trimester was 132.000,OR caused by natural delivery alone was 6.919,OR caused by the coexistence of serum RLX and natural delivery in the third trimester was 198.000,and the OR of interaction was smaller than that product of OR of serum RLX alone in the third trimes-ter and OR of natural delivery alone,which was the submultiplication model.Serum RLX in the third trimester had a positive interaction on the effect of natural delivery.The area under the curve(AUC)of serum RLX combined with delivery mode in predicting PFD was greater than that of serum RLX alone and delivery mode alone(P＜0.05)with the sensitivity and speci-ficity of 86.05%and 86.87%respectively.Conclusion The effects of serum RLX in the third trimester and mode of deliv-ery on PFD of primipara in the early postpartum period are consistent with the sub-multiplication model,and serum RLX in the third trimester play a positive interaction effect on natural delivery.The combination of serum RLX in the third trimester and mode of delivery can improve the ability to predict PFD of primipara in the early postpartum period.
维普
万方数据