摘要
目的 分析血清低密度脂蛋白胆固醇(LDL-C)/高密度脂蛋白胆固醇(HDL-C)、非高密度脂蛋白胆固醇(non-HDL-C)、残粒脂蛋白胆固醇(RLP-C)及可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)水平与老年急性脑梗死(ACI)的相关性.方法 选取2022 年1 月—2023 年8 月收治的 230 例老年ACI作为研究组,另选择同期、同年龄段115 例健康体检者作为对照组.比较2 组LDL-C/HDL-C、non-HDL-C、RLP-C及sLOX-1 水平,比较研究组不同斑块稳定性、神经功能缺损程度[采用美国国立卫生研究院卒中量表(NIHSS)评分评估]、颈动脉内中膜厚度(IMT)患者上述指标水平,偏回归分析上述指标与老年ACI的关系,并分析上述指标与斑块稳定性、IMT、NIHSS评分的相关性.结果 研究组LDL-C/HDL-C、non-HDL-C、RLP-C、sLOX-1 水平高于对照组(P＜0.01).老年 ACI患者 LDL-C/HDL-C、non-HDL-C、RLP-C及sLOX-1 水平,无斑块患者＜稳定斑块患者＜不稳定斑块患者,轻度神经功能缺损患者＜中度神经功能缺损患者＜重度神经功能缺损患者,IMT 正常患者＜IMT 增厚患者＜斑块形成患者(P＜0.05).LDL-C/HDL-C、non-HDL-C、RLP-C、sLOX-1 水平与老年ACI密切相关(P＜0.01).研究组LDL-C/HDL-C、non-HDL-C、RLP-C及sLOX-1 水平分别与斑块稳定性、IMT、NIHSS 评分呈正相关(P＜0.01).结论 老年 ACI 患者 LDL-C/HDL-C、non-HDL-C、RLP-C、sLOX-1 水平明显升高,且与神经功能缺损程度及颈动脉粥样硬化斑块密切相关.
Abstract
Objective To analyze the correlation of the levels of serum low-density lipoprotein cholesterol(LDL-C)/high-density lipoprotein cholesterol(HDL-C),non-high-density lipoprotein cholesterol(non-HDL-C),residual lipoprotein cholesterol(RLP-C)and soluble Lectin-like oxidized low density lipoprotein receptor-1(sLOX-1)with acute cerebral infarc-tion(ACI).Methods A total of 230 elderly ACI patients admitted from January 2022 to August 2023 were selected as the research group,and 115 healthy physical examinees of the same age group during the same period were selected as the control group.The levels of LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 were compared between the two groups,and the above levels of patients with different plaque stability,neurological deficit[assessed by the National Institutes of Health Stroke Scale(NIHSS)score]and carotid intimedia thickness(IMT)in the research group were compared.Partial regression analysis was performed to analyze the relationship between the above indexes and ACI,and the correlation between the above indexes and plaque stability,IMT and NIHSS score.Results LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels in the research group were higher than those in the control group(P＜0.01).For elderly ACI patients,LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels were lower in non-plaque patients,followed by stable plaque patients and unstable plaque patients,lower in mild neurological deficit patients,followed by moderate neurological deficit patients and severe neurological deficit pa-tients,and lower in normal IMT patients,followed by IMT thickening patients and plaque formation patients(P＜0.05).LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels were closely correlated with ACI in the elderly(P＜0.01).LDL-C/HDL-C,non-HDL-C,LDL-C and sLOX-1 levels in the research group were positively correlated with plaque stability,IMT and NIHSS score,respectively(P＜0.01).Conclusion LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels in elderly ACI patients are significantly increased,which is closely related to the degree of neurological deficit and carotid atherosclerotic plaque in patients,and provides guidance for clinical diagnosis and treatment.
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