临床误诊误治2024,Vol.37Issue(2) :1-6.DOI:10.3969/j.issn.1002-3429.2024.02.001

泌尿系结核误诊临床分析

Clinical Analysis of Misdiagnosis of Urinary Tuberculosis

谢平 王迎迎 蒋金利 马爽 陈彩萍
临床误诊误治2024,Vol.37Issue(2) :1-6.DOI:10.3969/j.issn.1002-3429.2024.02.001

泌尿系结核误诊临床分析

Clinical Analysis of Misdiagnosis of Urinary Tuberculosis

谢平 1王迎迎 1蒋金利 1马爽 1陈彩萍1
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作者信息

  • 1. 201600 上海,上海交通大学医学院附属松江医院感染科
  • 折叠

摘要

目的 探讨泌尿系结核(UTB)误诊原因,提高临床医师对该疾病的认识.方法 对2023 年2-7 月收治的UTB 5 例临床资料进行回顾性分析.结果 本组中临床表现尿频尿急4 例,血尿3 例,腰痛3 例,发热2 例;尿常规异常4 例,尿抗酸杆菌涂片阳性1 例,24h尿沉渣GeneXpert MTB/RIF阳性4 例,尿分枝杆菌培养阳性4 例,血结核感染T细胞斑点试验阳性5 例.影像学表现有肾积水、输尿管扩张及尿路钙化4 例,膀胱占位1 例,肾自截1 例.活动性肺结核3 例,陈旧性肺结核2 例.5 例延误诊治时间2~6 年.误诊为泌尿系感染合并肾结石2 例,泌尿系感染合并膀胱恶性肿瘤1 例,肾结石1 例,前列腺增生1 例;4 例确诊后予抗结核治疗,1 例未治疗,随访中2 例死亡.结论UTB由于临床表现缺乏特异性、早期诊断困难以及临床医师认识不足,容易误诊导致严重后果.对于复杂性尿路感染患者常规抗感染效果不佳,尤其是有胸部影像学异常时,需高度警惕UTB可能.

Abstract

Objective To explore the causes of misdiagnosis of urinary tuberculosis(UTB)and to improve the un-derstanding of the disease among clinicians.Methods The clinical data of 5 patients with UTB admitted from February to Ju-ly 2023 were retrospectively analyzed.Results In this group,there were 4 cases of frequent and urgent urination,3 cases of hematuria,3 cases of lumbago and 2 cases of fever.There were 4 cases with abnormal urine routine,1 case with positive urine acidobacter smear,4 cases with positive 24 h urine sediment GeneXpert MTB/RIF,4 cases with positive mycobacterium cul-ture,5 cases with positive T cell spot test of blood tuberculosis infection.The imaging findings included hydronephrosis,ure-teral dilation and urinary tract calcification in 4 cases,bladder occupying lesions in 1 case,and autonephrectomy in 1 case.There were 3 cases of active tuberculosis and 2 cases of old tuberculosis.All the 5 cases had delayed diagnosis and treatment for 2-6 years.They were misdiagnosed as urinary tract infection combined with kidney stone in 2 cases,urinary tract infection combined with bladder malignant tumor in 1 case,kidney stone in 1 case,and prostatic hyperplasia in 1 case.Four patients were treated with antituberculosis therapy,one was left untreated,and two died during follow-up.Conclusion Due to the lack of specificity in clinical manifestations,difficulty in early diagnosis,and insufficient understanding of clinicians,urinary tuberculosis is more likely to be misdiagnosed,leading to serious consequences.For patients with complex urinary tract infec-tions and poor conventional anti-infection effects,especially when there are pulmonary imaging abnormalities,it is necessary to be highly vigilant about the possibility of urinary tuberculosis.

关键词

结核,泌尿生殖系统/结核分枝杆菌/误诊/泌尿系感染/肾结石/前列腺增生/结核感染T细胞斑点试验/抗结核药

Key words

Tuberculosis,urogenital/Mycobacterium tuberculosis/Misdiagnosis/Urinary tract infection/Kidney stones/Prostatic hyperplasia/T cell spot test for tuberculosis infection/Antitubercular agents

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基金项目

上海市松江区公共卫生体系建设三年行动计划(2023-2025)(SJGW6-10)

出版年

2024
临床误诊误治
解放军白求恩国际和平医院

临床误诊误治

CSTPCD
影响因子:0.914
ISSN:1002-3429
参考文献量23
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