Objective To summarize and analyze the clinical characteristics,causes of misdiagnosis and preventive measures for senile degenerative heart valvular disease(SDHVD).Methods Clinical data of 15 patients with SDHVD ad-mitted to our hospital from January 2020 to December 2022 after misdiagnosis in other hospitals were retrospectively analyzed.Results Among the 15 patients,there were 8 patients with simple aortic valve disease,5 patients with mitral valve disease,and 2 patients with double aortic and mitral valve disease.Past medical history included hypertension(n =8),hyperlipidemia(n =6),type 2 diabetes(n =4),chronic obstructive pulmonary disease(n =3),and stroke(n =2).There were 7 patients with smoking history.Ten patients were initially diagnosed as coronary heart disease(CHD)due to different degrees of palpi-tation,chest tightness,shortness of breath,weakness and pain in the precordial area.For 5 patients with different degrees of palpitation,chest tightness,shortness of breath,weakness and lower limb edema,auscultation found heart murmur,prelimi-nary diagnosis of rheumatic heart disease was made.The misdiagnosis lasted 0.5 to 2 months.For the patient initially diag-nosed with CHD the symptoms did not show significant relief after drug treatment.Patients with initial diagnosis of rheumatic heart disease did not receive any treatment and were referred to our hospital for further treatment.After the 15 patients were admitted to our hospital,according to clinical manifestations,high-pressure X-ray tomography and echocardiography examina-tion,SDHVD was confirmed.Six patients were treated with interventional therapy and then lost to follow-up,and 9 patients were given conservative drug therapy,and calcification of the damaged valve was well controlled at 1-year follow-up.Conclu-sion There are usually no obvious symptoms in the early stage of SDHVD,or the symptoms are slightly covered by the symp-toms of the underlying diseases of the elderly.In addition,some patients have the characteristics of slow development of heart valve murmurs,often resulting in misdiagnosis.To improve the receiving doctors'cognition of the disease,enrich their experi-ence in diagnosis and differential diagnosis,and perform high-pressure X-ray tomography and echocardiography as soon as pos-sible is necessary to reduce or avoid misdiagnosis and mistreatment of this disease.