Objective To investigate the application value of minimally invasive percutaneous plate osteosynthesis(MIPPO)in locking plate fixation for midclavicular comminuted fracture.Methods The clinical data of 130 patients with mid-clavicular comminted fracture from June 2020 to June 2022 were retrospectively selected and divided into observation group(n = 65)and control group(n =65)according to the surgical method.The control group was treated with traditional open reduction and internal fixation,and the observation group was treated with MIPPO technique combined with locking plate.Perioperative in-dexes,complications,excellence and good rate of surgery,pain stress mediators before and after surgery,and shoulder joint function indexes were compared between the two groups.Results The incision length and fracture healing time of the observa-tion group were shorter than those of the control group,the amount of blood loss during operation was less than that of the control group,and the visual analogue scale score at 1 d after operation was lower than that of the control group(P<0.01).At 1 d af-ter operation,serum substance P and prostaglandin E2 in the observation group were lower than those in the control group,while β endorphin was higher than that in the control group(P<0.05).At 3 and 6 months after operation,the Constant-Murley shoulder function score and shoulder flexion,extension and rotation of the observation group were higher than those of the control group(P<0.05).The total complication rate of the observation group was lower than that of the control group,and the excel-lent and good rate of surgery at 6 months after the operation was higher than that of the control group(P<0.05).Conclusion MIPPO technique combined with locking plate in the treatment of midclavicular comminuted fracture can significantly improve the excellent and good rate surgery,reduce intraoperative blood loss,promote the recovery of shoulder joint function,inhibit the re-lease of pain factors,relieve early postoperative pain,and reduce the risk of complications.