摘要
目的 探究子宫肌瘤合并中度贫血患者术前采用米非司酮及醋酸亮丙瑞林对子宫体积、血红蛋白及性激素水平的影响.方法 选取2022 年5 月—2023 年1 月收治的子宫肌瘤合并中度贫血100 例,随机分为研究组和对照组,各50 例.2 组均采用琥珀酸亚铁缓释片纠正贫血,对照组采用米非司酮治疗,研究组采用醋酸亮丙瑞林联合米非司酮治疗,治疗周期均为3 个月.比较2 组治疗效果、子宫体积、子宫肌瘤体积、贫血相关指标[血红蛋白(Hb)、红细胞计数(RBC)、红细胞平均体积(MCV)]、性激素[黄体生成素(LH)、雌二醇(E2)、卵泡刺激素(FSH)]、炎症-应激因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)、超氧化物歧化酶(SOD)],记录2 组不良反应发生情况.结果 研究组总有效率[96.00%(48/50)]高于对照组[80.00%(40/50)](P<0.05);研究组治疗 1、2、3个月后子宫体积、子宫肌瘤体积小于对照组,外周血 Hb、RBC、MCV 水平高于对照组,血清 LH、E2、FSH 及 IL-6、TNF-α、MDA水平低于对照组,SOD水平高于对照组(P<0.05).2 组治疗期间不良反应发生率比较差异无统计学意义(P>0.05).结论 术前采用米非司酮联合醋酸亮丙瑞林治疗子宫肌瘤合并中度贫血患者临床效果较好,进一步缩小子宫体积及子宫肌瘤体积,改善性激素水平,纠正贫血状态.
Abstract
Objective To investigate the effects of Mifepristone and Leuprelin Acetate on uterine volume,hemoglobin and sex hormone levels in patients with uterine fibroids(UF)complicated with moderate anemia.Methods In total,100 pa-tients with UF complicated with moderate anemia treated from May 2022 to January 2023 were selected and randomly divided into research group(n =50)and control group(n =50).The two groups were treated with Ferrous Succinate sustained re-lease tablets to correct anemia,the control group was treated with Mifepristone,and the research group was treated with Leu-prelin Acetate combined with Mifepristone.The treatment cycle was 3 months.The therapeutic effect,uterine volume,UF volume,anema-related indexes[hemoglobin(Hb),red blood cell count(RBC),mean red blood cell volume(MCV)],sex hormone[luteinizing hormone(LH),estradiol(E2),follicle stimulating hormone(FSH)],inflammatory stress factors[in-terleukin-6(IL-6),tumor necrosis factor-α(TNF-α),malondialdehyde(MDA),superoxide dismutase(SOD)]were com-pared between the two groups,and the occurrence of adverse reactions in the two groups were recorded.Results The total ef-fective rate of the research group[96.00%(48/50)]was higher than that of the control group[80.00%(40/50)](P<0.05).At 1,2 and 3 months after treatment,the uterine volume and UF volume of the research group were smaller than those of the control group,and the levels of Hb,RBC and MCV in peripheral blood were higher than those of the control group;the levels of serum LH,E2,FSH,IL-6,TNF-α and MDA were lower than those of the control group,while the level of SOD was higher than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Preoperative use of Mifepristone combined with Leuprelin Acetate in the treatment of UF patients with moderate anemia is effective in clinical treatment,further reduce the uterine volume and UF vol-ume,improve the level of sex hormones,and correct the anemia.
基金项目
河北省中医药局科研项目(2019543)
张家口市重点研发计划自筹经费项目(2221132D)
维普
万方数据