Objective To investigate the interaction between triacylglycerol(TG)and apolipoprotein E(APOE)gene polymorphisms in the occurrence of acute cerebral infarction(ACI)in patients with transient ischemic attack(TIA).Methods A total of 349 patients TIA from January 2019 to June 2021 were followed up for 6 months.They were divided into occurrence group and non-occurrence group according to presence of ACI.The general data,total cholesterol(TC),low den-sity lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),TG and APOE gene polymorphism of the two groups were compared.Furthermore,APOE gene polymorphism in patients with different TG levels was compared,and the influencing factors of TIA complicated with ACI were analyzed by multivariate Logistic regression analysis.Interaction coeffi-cient γ was used to analyze the interaction between TG and APOE gene polymorphism and the type of interaction.Results At 6 months after follow-up,a total of 45(12.89%)TIA patients experienced ACI.The TG of occurrence group was higher than that of non-occurrence group(P＜0.01).The frequency of E3/3 genotype and ε3 allele in occurrence group and patients with increased TG were lower than those in non-occurrence group and patients without noraml TG,respectively,while the frequency of E3/4 genotype and ε4 allele were higher than those in non-occurrence group and patients with normal TG respectively(P＜0.05).After adjusting for the duration and frequency of TIA,TG,APOE genotype E3/3,E3/4 and ε4 alleles were still the independent influencing factors of TIA complicated with ACI(P＜0.01).The increase of TG and APOE genotype E3/4 had a positive interaction in TIA complicated with ACI,and the interaction was consistent with the submultiplicative model.Con-clusion The increase of TG positively interacts with APOE genotype E3/4 in TIA complicated with ACI,and the interaction is consistent with the submultiplicative model.The increase of TG can enhance the susceptibility of APOE genotype E3/4 to TIA complicated with ACI.
维普
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