摘要
目的 探讨奥曲肽联合胰岛素治疗糖尿病酮症酸中毒(DKA)的效果.方法 选取2021 年1 月—2023年5 月收治的DKA 106 例,按照随机数字表法将其分为研究组和对照组2 组各53 例.研究组给予奥曲肽联合胰岛素加补液急救措施治疗,对照组给予胰岛素加补液急救措施治疗.比较 2 组治疗效果、临床症状和体征改善情况、酸中毒指标[血乳酸(Lac)、β-羟丁酸(β-HB)、硫胺素、二氧化碳结合力(CO2 CP)]、炎性因子[白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、C 反应蛋白(CRP)]及不良事件发生情况.结果 研究组总有效率93.34%(50/53)高于对照组81.13%(43/53)(P＜0.05).研究组血酮体转阴时间、尿酮体转阴时间和pH纠正时间短于对照组(P＜0.01).治疗1 周后,2 组Lac、β-HB和IL-6、IL-10、TNF-α、CRP较治疗前下降,且研究组低于对照组;硫胺素和CO2 CP较治疗前升高,且研究组高于对照组(P＜0.05,P＜0.01).治疗期间,研究组不良事件发生率与对照组相比无显著差异(P＞0.05).结论 奥曲肽联合胰岛素加补液急救措施治疗DKA患者效果确切且安全,可显著改善患者临床症状,调控炎性因子.
Abstract
Objective To investigate the effect of Octreotide combined with insulin in the treatment of diabetic keto-acidosis(DKA).Methods A total of 106 patients with DKA treated from January 2021 to May 2023 were selected and di-vided into research group(n=53)and control group(n=53)according to random number table method.The research group was treated with Octreotide combined with insulin and rehydration solution as emergency measures,while the control group was treated with insulin and rehydration solution as emergency measures.The therapeutic effect,improvement of clinical symptoms and signs,acidosis indexes[blood lactic acid(Lac),β-hydroxybutyric acid(β-HB),thiamine,carbon dioxide combining power(CO2 CP)],inflammatory factors[interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]before and after treatment,as well as incidence of adverse events,were compared between the two groups.Results The total effective rate of the research group was 93.34%(50/53),which was higher than that of the con-trol group[81.13%(43/53)](P＜0.05).Time to positive-to-negative conversion of blood ketone body,time to positive-to-negative conversion of urine ketone body and time to pH correction were shorter in the research group than in the control group(P＜0.01).At 1 week after treatment,Lac,β-HB,IL-6,IL-10,TNF-α and CRP in the two groups were lower than those before treatment,and lower in the research group than in the control group,while thiamine and CO2 CP were higher than those before treatment,and higher in the research group than in the control group(P＜0.05,P＜0.01).There was no signif-icant difference in the incidence of adverse events between the research group and the control group during treatment(P＞0.05).Conclusion Octreotide combined with insulin and rehydration solution as emergency measures is effective and safe in the treatment of DKA patients,which can significantly improve clinical symptoms and regulate inflammatory factors.
国家科技期刊平台
NSTL
万方数据