Objective To investigate the effects of Glucosamine Sulfate combined with Meloxicam on the levels of se-rum fibroblast growth factor-2(FGF-2),transforming growth factor-β(TGF-β),insulin-like growth factor-1(IGF-1)and knee motor function in patients with knee osteoarthritis(KOA).Methods A total of 114 patients with KOA were selected from June 2021 to June 2023 and divided into the combination group(n=57)and Meloxicam group(n=57)by random number table method.The Meloxicam group was treated with Meloxicam tablets,and the combination group was supplemented with Glucosamine Sulfate capsules based on the Meloxicam group for 6 weeks.The therapeutic effect of the two groups at 6 weeks after treatment was observed,and the knee joint motor function indexes,inflammatory factors,growth factors levels and safety during treatment were compared between the two groups before and at 6 weeks after treatment.Results At 6 weeks after treatment,the total effective rate of combination group was 91.23%(52/57),which was higher than that of Meloxicam group[73.68%(42/57)](P＜0.05).At 6 weeks after treatment,the time required for 5 times sit-to-stand(5-STS)test and 2.4 m Timed Up and Go(TUG)test in the two groups was shorter than that before treatment,which was shorter in the combination group than the Meloxicam group(P＜0.05,P＜0.01).Western Ontario and McMaster University osteoarthritis index scores and serum prostaglandin E2,interleukin-17,matrix metalloproteinase-3 levels were lower than those before treatment,which were lower in the combination group than in the Meloxicam group(P＜0.05,P＜0.01).At 6 weeks after treatment,the serum levels of FGF-2,TGF-β and IGF-1 in the two groups were higher than those before treatment,which were higher in the combina-tion group than in the Meloxicam group(P＜0.05,P＜0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Glucosamine Sulfate combined with Meloxicam can effectively in-crease the levels of serum FGF-2,TGF-β and IGF-1 in patients with KOA,delay cartilage degeneration,control the inflammato-ry response,and then effectively improve the knee joint motor function of patients,showing significant efficacy and good safety.
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