血清维生素B12、25(OH)D水平对老年抑郁症患者预后的影响及与病情程度的相关性
Effect of Serum Vitamin B12 and 25(OH)D Levels on the Progno-sis of Elderly Patients with Depression and Their Correlation with the Severity of the Disease
何叶亭 1赵颖逾 2齐佳悦 1赵艳名 3魏昆岭 4朱慧颖 2陈宏美 5王丽娜6
作者信息
- 1. 066000 河北秦皇岛,秦皇岛市九龙山医院老年科
- 2. 066000 河北秦皇岛,秦皇岛市九龙山医院临床心理科
- 3. 066000 河北秦皇岛,秦皇岛市九龙山医院人事科
- 4. 071000 河北保定,河北省第六人民医院睡眠医学科
- 5. 066000 河北秦皇岛,秦皇岛市九龙山医院质控办
- 6. 071000 河北保定,河北省第六人民医院临床心理科
- 折叠
摘要
目的 观察老年抑郁症患者血清维生素B12和25羟维生素D[25-hydroxy vitamin D,25(OH)D]水平,并分析二者对患者预后的影响及与病情程度的相关性.方法 选取2020年3月至2022年10月就诊的110例老年抑郁症患者,全部随访1年,以随访期间病情进展为难治性抑郁症为预后评判标准,分为预后良好组和预后不良组,比较2组基线资料、就诊当日血清维生素B12和25(OH)D水平,分析血清维生素B12、25(OH)D水平对患者预后的影响以及不同病情程度患者血清维生素B12、25(OH)D水平,并采用Pearson相关分析其与患者抑郁状态的相关性.结果 随访1年后,110例老年抑郁症患者中,29例病情进展为难治性抑郁症,发生率为26.36%;预后不良组血清维生素B12、25(OH)D水平均低于预后良好组(P＜0.01).多因素Logistic回归分析示,血清维生素B12和25(OH)D是老年抑郁症患者预后不良危险因素(P＜0.01).中度抑郁症患者血清维生素B12和25(OH)D低于轻度抑郁症患者(P＜0.01).相关性分析显示,血清维生素B12和25(OH)D水平与汉密尔顿抑郁量表评分呈负相关(r=-0.425、-0.326,P＜0.01).结论 血清维生素B12、25(OH)D水平可对老年抑郁症患者预后产生影响,预后越差的患者维生素B12和25(OH)D水平越低,二者水平检测可用于老年抑郁症患者病情的评估.
Abstract
Objective To observe the levels of serum vitamin B12 and 25 hydroxyvitamin D[25(OH)D]in elderly pa-tients with depression,and to analyze the effects of the two on the prognosis of patients and the correlation with the severity of the disease.Methods A total of 110 elderly patients with depression treated from March 2020 to October 2022 were selected and followed up for 1 year.The patients were divided into good prognosis group and poor prognosis group according to the pro-gression to refractory depression during follow-up as a prognostic criterion.The baseline data and serum vitamin B12 and 25 hy-droxyvitamin D[25(OH)D]levels of the two groups were compared on the day of treatment,and the impact of serum vitamin B12 and 25(OH)D levels on the prognosis of patients and the serum vitamin B12 and 25(OH)D levels of patients with different dis-ease severity were analyzed.Pearson correlation analysis was used to explore the correlation between the levels of the above in-dicators and depression.Results At 1-year follow-up,29 patients of 110 elderly patients with depression progressed to refrac-tory depression,with an incidence rate of 26.36%.The levels of vitamin B12 and 25(OH)D in the poor prognosis group were lower than those in the good prognosis group(P<0.01).Multivariate Logistic regression analysis showed that serum vitamin B12 and 25(OH)D were risk factors for poor prognosis in elderly patients with depression(P<0.01).Serum vitamin B12 and 25(OH)D in moderate depression patients were lower than those in mild depression patients(P<0.01).Correlation analysis showed that serum vitamin B12 and 25(OH)D levels were negatively correlated with Hamilton Depression Scale scores(r=-0.425,-0.326,P<0.01).Conclusion The serum levels of vitamin B12 and 25(OH)D can affect the prognosis of elderly patients with depression,and the poorer prognosis leads to the lower levels of vitamin B12 and 25(OH)D in patients.Therefore,the detection of both levels can be used to evaluate the condition of elderly patients with depression.
关键词
抑郁症/老年人/预后/维生素B12/25羟维生素D/病情程度/影响因素分析/相关性Key words
Depression/Elderly/Prognosis/Vitamin B12/25 hydroxyvitamin D/Severity of illness/Analysis of influ-encing factors/Correlation引用本文复制引用
基金项目
河北省2020年度医学科学研究课题计划项目(20200139)
出版年
2024
国家科技期刊平台
NSTL
万方数据