Objective To investigate the clinical characteristics,causes of misdiagnosis and preventive strategies of acute aortic syndrome(AAS).Methods A retrospective analysis was performed on 22 patients with AAS who had been misdi-agnosed as other diseases from January 2018 to December 2023.Results The main clinical manifestations of 22 patients were tearing,squeezing and constricting pain in the precardiac area in 10 patients,accompanied by back pain in 2 patients,chest tightness and shortness of breath in 5 patients,and dizziness alone in 2 patients,syncope accompanied by dull abdomi-nal pain in 1 patient,anorexia with fatigue in 1 patient,and headache,vomiting with fever in 1 patient.Eleven patients were misdiagnosed as acute coronary syndrome,of which 2 patients were misdiagnosed with acute myocardial infarction with specif-ic ST segment changes and increased troponin.One patient was misdiagnosed with cerebral infarction,and 2 patients with diz-ziness were diagnosed as transient ischemic attack.There were 2 patients misdiagnosed with chronic cardiac insufficiency,1 patient with diabetic ketoacidosis,1 patient with chronic obstructive pulmonary disease with acute exacerbation,1 patient with gout,1 patient with acute left heart failure and 1 patient with congenital heart disease.Misdiagnosis lasted from 2 h to 6 d.All the 22 patients were treated according to the misdiagnosed disease and the symptoms were not significantly relieved.Nineteen patients were diagnosed with major artery disease by CT angiography,2 were diagnosed by digital subtraction angiography,and 1 was diagnosed by thoracotomy exploration.After diagnosis,19 patients had good prognosis and 3 patients died.Conclu-sion AAS progresses rapidly,early detection and diagnosis are very important.By analyzing the disease,clinicians can deep-en the understanding of this kind of disease,improve rapid diagnosis rate of the disease,provide early and effective treatment,and improve patient prognosis.