Objective To investigate the clinical features,causes of misdiagnosis and preventive measures of gastro-esophageal reflux disease(GERD).Methods The clinical data of 5 patients with GERD who were misdiagnosed as bronchitis from December 2022 to November 2023 were retrospectively analyzed.Results The main complaint of the 5 patients was re-peated cough.The cough symptom was serious at night,accompanied by chest tightness and chest pain in 3 patients,pharyn-geal pain in 2 patients,sputum in 3 patients,asthma in 1 patient,sleep disorder in 1 patient and shortness of breath in 1 pa-tient.All the 5 patients were misdiagnosed as bronchitis,and the misdiagnosis lasted 15 d-3 years.All patients were diag-nosed with GERD after 24 h of esophageal pH monitoring and electronic gastroscopy,and one patient showed improvement in symptoms after receiving proton pump inhibitor test.They were diagnosed with GERD.After diagnosis,the corresponding treatment was given,and the symptoms completely disappeared with no recurrence.Conclusion The clinical manifestations of GERD are complex and varied,especially in patients with extraesophageal symptoms;therefore,it is more likely to be mis-diagnosed as bronchitis.At the first visit,doctors should strengthen the understanding of the extraesophageal symptoms of this disease,improve the ability of differential diagnosis of the two diseases,perform the relevant examination,and improve the di-agnosis rate,so that patients can receive timely and appropriate treatment.
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