临床误诊误治2024，Vol.37Issue(12) ：46-49.DOI:10.3969/j.issn.1002-3429.2024.12.010

经鼻高流量湿化氧疗联合糖皮质激素治疗重症哮喘短期疗效及对炎性因子水平的影响

Short-term Efficacy of High-flow Nasal Cannula Oxygen Thera-py Combined with Glucocorticoid in the Treatment of Severe Asthma and Its Effect on Inflammatory Factors

江美芳 秦克 刘蔺 江艺 刘翠翠 石开勤 陈东林
临床误诊误治2024，Vol.37Issue(12) ：46-49.DOI:10.3969/j.issn.1002-3429.2024.12.010
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经鼻高流量湿化氧疗联合糖皮质激素治疗重症哮喘短期疗效及对炎性因子水平的影响

Short-term Efficacy of High-flow Nasal Cannula Oxygen Thera-py Combined with Glucocorticoid in the Treatment of Severe Asthma and Its Effect on Inflammatory Factors

江美芳 1秦克 1刘蔺 1江艺 1刘翠翠 2石开勤 1陈东林3
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作者信息

  • 1. 610000 成都,三六三医院呼吸与危重症医学科
  • 2. 610000 成都,三六三医院神经外科
  • 3. 719000 陕西榆林,榆林市第一医院重症医学科
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摘要

目的 探讨经鼻高流量湿化氧疗(HFNC)联合糖皮质激素治疗重症哮喘短期效果及对炎性因子水平的影响.方法 选择2020年5月至2022年5月收治的重症哮喘患者100例,随机分为观察组和对照组各50例.对照组给予甲泼尼龙治疗,观察组在对照组基础上联合HFNC治疗.比较2组临床疗效、血气指标[动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、血氧饱和度(SpO2)]、炎性因子水平变化以及不良反应发生情况.结果 观察组总有效率[96.00％(48/50)]显著高于对照组[82.00％(41/50)](P＜0.05);观察组PaO2、SpO2高于对照组,PaCO2低于对照组(P＜0.05);治疗后观察组炎性因子水平低于对照组(P＜0.05);2组不良反应发生率比较差异无统计学意义(P＞0.05).结论 HFNC联合糖皮质激素治疗重症哮喘患者效果更佳,可显著改善患者呼吸功能,调节炎性因子水平,不增加不良反应.

Abstract

Objective To investigate the short-term effect of high-flow nasal cannula oxygen therapy(HFNC)com-bined with Glucocorticoid in the treatment of severe asthma and their effect on the level of inflammatory factors.Methods A total of 100 patients with severe asthma admitted from May 2020 to May 2022 were randomly divided into observation group and control group,with 50 patients in each group.The control group was treated with Methylprednisolone and the observation group was treated with HFNC on the basis of the control group.The clinical efficacy,blood gas indexes[arterial partial pres-sure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),blood oxygen saturation(SpO2)],inflammatory factors and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of observa-tion group[96.00％(48/50)]was significantly higher than that of control group[82.00％(41/50)](P＜0.05).PaO2 and SpO2 were higher in observation group than in the control group while PaCO2 was lower in observation group than in the control group(P＜0.05).After treatment,the level of inflammatory factors in observation group was lower than that in control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion HFNC combined with Glucocorticoids is more effective in the treatment of severe asthma patients,which can significantly improve the respiratory function of patients,regulate the level of inflammatory factors,and do not increase adverse reactions.

关键词

哮喘/糖皮质激素/经鼻高流量湿化氧疗/Toll样受体4/白细胞介素-6/嗜酸粒细胞/干扰素-γ

Key words

Asthma/Glucocorticoid/High-flow nasal cannula oxygen therapy/Toll like receptor 4/Interleukin-6/Eosinophil/Interferon-γ

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基金项目

四川省医学科研课题计划(S20041)

成都市医学科研课题(2022436)

出版年

2024
临床误诊误治
解放军白求恩国际和平医院

临床误诊误治

CSTPCD
影响因子：0.914
ISSN：1002-3429
参考文献量16
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