Effect of Multi-mode CT-guided Intra-arterial Thrombolysis on Oxidative Stress,Inflammatory Response and Neurological Func-tion in Patients with Acute Disabling Non-macrovascular Cere-bral Infarction
Effect of Multi-mode CT-guided Intra-arterial Thrombolysis on Oxidative Stress,Inflammatory Response and Neurological Func-tion in Patients with Acute Disabling Non-macrovascular Cere-bral Infarction
Objective To investigate the application value of intra-arterial thrombolysis under the guidance of multi-mode CT in the treatment of acute disabling non-macrovascular cerebral infarction.Methods Clinical data of 80 patients with acute disabling non-macrovascular cerebral infarction treated from January 2022 to December 2023 were retrospectively analyzed,and they were divided into observation group(n=40)and control group(n=40)according to treatment plan.The ob-servation group received intra-arterial thrombolysis under the guidance of multi-mode CT,and the control group received intra-venous thrombolysis.The clinical efficacy,degree of nerve function injury[National Institute of Health stroke scale(NIHSS)score]before and after thrombolysis,oxidative stress index[superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),malondialdehyde(MDA)],inflammatory response index[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitivity C reactive protein(hs-CRP)],vascular recanalization and adverse events were compared between the two groups.Results There was no significant difference in total effective rate between the two groups(P＞0.05).At 2 h,24 h,7 d and 30 d after thrombolysis,the NIHSS score of the observation group was lower than that of the control group(P＜0.05).At 7 d and 30 d af-ter thrombolysis,SOD and GSH-Px levels in observation group were higher than those in control group,while MDA,IL-6,hs-CRP and TNF-α levels were lower than those in control group(P＜0.0l).There was no significant difference in the rate of vascular revascularization and the incidence of adverse events between the two groups(P＞0.05).Conclusion The efficacy and safety of intra-arterial thrombolysis under the guidance of multi-mode CT are comparable to those of intravenous thrombol-ysis,but intra-arterial thrombolysis can reduce inflammation and oxidative stress damage and improve nerve function.
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