外周血TIMP-1、TIMP-2及TSAT水平与腹膜透析相关性腹膜炎患者临床转归的关系
Relationship between Peripheral Blood TIMP-1,TIMP-2,TSAT Level and Clinical Outcomes in Patients with Peritoneal Dialysis-associated Peritonitis
李雅琪 1郭宝珠 2程锦绣 2金玉杰2
作者信息
- 1. 075000 河北张家口,河北北方学院附属第一医院慢病管理科
- 2. 075000 河北张家口,河北北方学院附属第一医院肾内科
- 折叠
摘要
目的 分析腹膜透析相关性腹膜炎患者外周血基质金属蛋白酶抑制因子-1(TIMP-1)、基质金属蛋白酶抑制因子-2(TIMP-2)和转铁蛋白饱和度(TSAT)水平与临床转归的关系.方法 选取 2021 年 8 月至 2023 年 2 月收治的100 例腹膜透析相关性腹膜炎患者,根据患者拔除腹膜透析管后 1 年内临床转归情况将其分为治愈组(n=68)和恶化组(n=32).比较2 组临床资料及外周血TIMP-1、TIMP-2 及TSAT水平,采用多因素Logistic回归分析影响腹膜透析相关性腹膜炎患者病情恶化的独立危险因素,采用受试者工作特征(ROC)曲线分析TIMP-1、TIMP-2 及TSAT对患者临床转归的预测价值.结果 恶化组透析龄高于治愈组,有腹膜炎病史患者占比大于治愈组,TIMP-1、TIMP-2和TSAT水平低于治愈组(P＜0.01).TIMP-1、TIMP-2 和TSAT水平过低均是腹膜透析相关性腹膜炎患者病情恶化的独立危险因素(P＜0.05).ROC曲线分析显示,TIMP-1、TIMP-2 和TSAT预测腹膜透析相关性腹膜炎患者临床转归的曲线下面积(AUC)分别为0.759、0.702 和 0.739,上述指标联合检测的 AUC为 0.813,具有更好的预测价值(P＜0.05).结论 病情恶化的腹膜透析相关性腹膜炎患者TIMP-1、TIMP-2 和TSAT水平降低,且三者及其联合检测对患者临床转归均有较高的预测价值.
Abstract
Objective To analyze the levels of tissue inhibitor of metalloproteinase-1(TIMP-1),tissue inhibitor of metalloproteinase-2(TIMP-2)and transferrin saturation(TSAT)in peripheral blood of peritoneal dialysis-associated peritoni-tis(PDAP)patients and their relationship with clinical outcomes.Methods A total of 100 patients with PDAP admitted from August 2021 to February 2023 were selected and divided into cure group(n=68)and worsening group(n=32)according to their clinical outcomes within 1 year after removal of peritoneal dialysis tube.The clinical data and peripheral blood TIMP-1,TIMP-2 and TSAT levels were compared between the two groups.Multivariate Logistic regression analysis was used to analyze the independent risk factors for the deterioration of PDAP in those patients.The predictive value of TIMP-1,TIMP-2 and TSAT for clinical outcome of patients was analyzed by receiver operating characteristic(ROC)curve.Results The dialysis age in the worsening group was higher than that in the cure group,the proportion of patients with history of peritonitis was higher than that in the cure group,and the TIMP-1,TIMP-2 and TSAT levels were lower than those in the cure group(P＜0.01).Low levels of TIMP-1,TIMP-2 and TSAT were independent risk factors for deterioration of PDAP in those patients(P＜0.05).ROC curve analysis showed that the area under the ROC curve(AUC)of TIMP-1,TIMP-2 and TSAT in predic-ting the clinical outcome of PDAP patients were 0.759,0.702 and 0.739,respectively,and that the AUC of the combined detection of the above indicators was 0.813,which had better predictive value(P＜0.05).Conclusion TIMP-1,TIMP-2 and TSAT levels were reduced in PDAP patients with worsening disease,and the three factors detected alone and in combina-tion had high predictive value for clinical outcomes of patients.
关键词
腹膜透析/腹膜炎/基质金属蛋白酶抑制因子-1/基质金属蛋白酶抑制因子-2/转铁蛋白饱和度/临床转归/危险因素/受试者工作特征曲线Key words
Peritoneal dialysis/Peritonitis/Tissue inhibitor of metalloproteinase-1/Tissue inhibitor of metalloprotei-nase-2/Transferrin saturation/Clinical outcome/Risk factors/Receiver operating characteristic curve引用本文复制引用
基金项目
河北省卫生健康委员会医学科学研究项目(20231411)
出版年
2024
国家科技期刊平台
NSTL
万方数据