联合辛麻颗粒对慢性阻塞性肺疾病急性加重期外寒内饮证患者临床疗效和免疫功能的影响
Effect of Combined Xinma Granules on Clinical Efficacy and Immune Function of Patients with Syndrome of External Cold and Internal Fluid Retention Dur-ing Acute Exacerbation of Chronic Obstructive Pulmonary Disease
宫静 1吕子怡 1吴淼萍 1钟邓萍 1伍梅樱 1赵丽芸1
作者信息
- 1. 510000 广州,广州中医药大学第五临床医学院
- 折叠
摘要
目的 观察慢性阻塞性肺疾病急性加重期外寒内饮证患者联合辛麻颗粒治疗的临床疗效.方法 选择2023 年8 月至2024 年4 月收治的60 例慢性阻塞性肺疾病急性加重期外寒内饮证患者,根据治疗方法分为对照组(n=30)和观察组(n=30).对照组采用常规西药治疗,观察组采用常规西药联合辛麻颗粒治疗.比较 2 组临床疗效、血气分析[动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、血氧饱和度(SaO2)]、免疫指标及不良反应.结果 2 组总有效率观察组96.67%(29/30)高于对照组 73.33%(22/30)(P＜0.05).治疗后,观察组PaO2、SaO2、IgA、IgG、IgM、CD3+、CD4+、CD4+/CD8+高于对照组,PaCO2、CD8+低于对照组(P＜0.05).2 组不良反应发生率比较无统计学差异(P＞0.05).结论 慢性阻塞性肺疾病急性加重期外寒内饮证患者采用常规西药联合辛麻颗粒治疗,对免疫功能、血气分析指标有明显的改善作用,临床疗效较好、安全性较高.
Abstract
Objective To observe the clinical effect of combined Xinma granules in the treatment of patients with syndrome of external cold and internal fluid retention during acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods From August 2023 to April 2024,60 patients with syndrome of external cold and internal fluid reten-tion during AECOPD were selected and divided into control group(n=30)and observation group(n=30)according to treat-ment methods.The control group was treated with conventional Western medicine,and the observation group was treated with conventional Western medicine combined with Xinma granules.The clinical efficacy,blood gas analysis[arterial partial pres-sure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),and blood oxygen saturation(SaO2)],immune indexes and adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 96.67%(29/30),which was higher than that of the control group[73.33%(22/30)](P＜0.05).After treatment,PaO2,SaO2,IgA,IgG,IgM,CD3+,CD4+,and CD4+/CD8+in observation group were higher than those in control group,while PaCO2 and CD8+were lower than those in control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Conventional Western medicine combined with Xinma granules can significantly improve the immune function and blood gas analysis indexes of patients with syndrome of external cold and internal fluid retention during AECOPD,with good clinical efficacy and safety.
关键词
慢性阻塞性肺疾病/急性加重期/辛麻颗粒/外寒内饮证/血气分析/免疫球蛋白/T淋巴细胞亚群Key words
Chronic obstructive pulmonary disease/Acute exacerbation stage/Xinma granules/Syndrome of external cold and internal fluid retention/Blood gas analysis/Immunoglobulin/T-lymphocyte subsets引用本文复制引用
基金项目
广东省中医药管理局基金(20211028)
出版年
2024
国家科技期刊平台
NSTL
万方数据