Objective To investigate the clinical characteristics,causes of misdiagnosis,and preventive measures of renal angiomyolipoma(RAML)and renal cell carcinoma(RCC).Methods Retrospective analysis was performed on clinical data of 12 patients with preoperative diagnosis of RCC and postoperative pathological confirmation of RAML admitted to our hospital from July 2018 to May 2023.Results All 12 lesions were located in one kidney,including 5 patients on the left side and 7 patients on the right side.Two patients were detected during hospitalization after trauma,and 10 patients were detected during physical examination.They were misdiagnosed with renal cancer during preoperative imaging examinations.Misdiagno-sis lasted 5-8 d.All patients underwent surgical treatment,including 1 patient undergoing open surgery and 11 patients under-going laparoscopic surgery.Nine patients underwent partial nephrectomy and 3 patients underwent radical nephrectomy.The postoperative pathology confirmed RAML in all patients.At 1-year follow-up,there was no recurrence.Conclusion RAML is prone to misdiagnosis as RCC,especially for tumors with smaller diameter and less fat.For RCC whose preoperative nature is difficult to determine,especially when the maximum diameter of tumor is<4 cm,partial nephrectomy can be considered to avoid overtreatment.