Objective To analyze the clinical manifestations and causes of early misdiagnosis of contrast-induced en-cephalopathy(CIE)after carotid artery stenting(CAS).Methods A retrospective analysis was conducted on the clinical data of 5 patients with CIE misdiagnosed after CAS treated from September 2020 to April 2024.Results One patient devel-oped progressive consciousness disorders,mixed aphasia,bilateral delayed pupillary light reflex,and right-sided limb weak-ness at 2 h after surgery.High fever,epileptic seizures,and hemiplegia occurred at 7 h after surgery,which were misdiag-nosed as subarachnoid hemorrhage based on CT examination.Four patients developed acute aphasia and hemiplegia at 2-6 h postoperatively,which were misdiagnosed as lacunar cerebral infarction based on CT examination.All 5 patients received cor-responding treatment and were confirmed to have CIE through follow-up head CT scans.The misdiagnosis lasted 12-48 h.Af-ter treatment,the symptoms of acute aphasia and hemiplegia were improved,and there were no consciousness disorders or epi-leptic seizures.Conclusion CIE symptoms after CAS are often atypical and it is prone to misdiagnosis.Clinicians should an-alyze the condition comprehensively,to promptly rule out primary neurological disorders.