Therapeutic Effect of Vitamin D and Metformin in Patients with Gestation-al Diabetes Mellitus and Their Impact on Pregnancy Outcomes and Retinol-binding Protein 4
Therapeutic Effect of Vitamin D and Metformin in Patients with Gestation-al Diabetes Mellitus and Their Impact on Pregnancy Outcomes and Retinol-binding Protein 4
Objective To analyze the therapeutic effect of Vitamin D and Metformin in patients with gestational dia-betes mellitus(GDM).Methods A total of 200 patients with GDM admitted from March 2023 to March 2024 were selected and divided into the control group(n=100)and the observation group(n=100)according to random number table method.The control group received Metformin treatment,and the observation group was supplemented with Vitamin D treatment on the basis of the control group.Glucose metabolism indexes,renal function,serum factors[tumor necrosis factor-α(TNF-α),retinol-binding protein 4(RBP4)and visfatin]and lipid indexes[triacylglycerol(TG),total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)]were compared between the two groups.Pregnancy outcome and adverse reactions were observed in the two groups.Results Fasting blood glucose,2 h postmeal blood glucose,glycated hemoglobin,steady-state model insulin resistance index,TNF-α,RBP4,visfatin,TC,TG and LDL-C in the observation group after treatment were lower than those in the control group,while fasting insulin was higher than that in the control group(P＜0.05).After treatment,serum creatinine,24 h urinary protein and blood urea in the two groups were lower than those before treatment,which were lower in the observation group than in the control group(P＜0.05).The incidence of macrosomia,postpartum hemorrhage,neonatal asphyxia and the total incidence of adverse reactions in the observation group were lower than those in the control group(P＜0.05).Conclusion The combination of Vitamin D and Metformin in the treatment of GDM has a bet-ter effect,which can maintain the body's glucose metabolism and lipid levels,regulate kidney function,and stabilize RBP4 level,thereby improving the pregnancy outcome and controlling adverse reactions.
关键词
妊娠期糖尿病/维生素D/二甲双胍/妊娠结局/视黄醇结合蛋白4/血糖/血肌酐/不良反应
Key words
Gestational diabetes mellitus/Vitamin D/Metformin/Pregnancy outcome/Retinal-binding protein 4/Blood glucose/Serum creatinine/Adverse reaction
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