Value of Pulmonary Ultrasound and Human Body Composition Analysis in Volume Load Assessment of Uremic Patients Undergoing Peritoneal Dialy-sis and Their Relationship with N-terminal Pro-brain Natriuretic Peptide
Value of Pulmonary Ultrasound and Human Body Composition Analysis in Volume Load Assessment of Uremic Patients Undergoing Peritoneal Dialy-sis and Their Relationship with N-terminal Pro-brain Natriuretic Peptide
Objective To explore the value of pulmonary ultrasound and human body composition analysis in volume load assessment of uremic patients undergoing peritoneal dialysis,and to analyze the relationship between pulmonary ultra-sound,human body composition analysis,and serum N-terminal pro-brain natriuretic peptide(NT-proBNP).Methods A total of 50 patients with high volume load in uremia undergoing peritoneal dialysis from June 2020 to December 2022 were se-lected as the observation group,and another 50 patients with normal volume load undergoing peritoneal dialysis were selected as the control group.The blood pressure,heart rate and blood biochemical indexes of the two groups were compared,and the occurrence of adverse reactions was observed.The lung ultrasound indexes and human body composition indexes of the two groups were compared,the lung ultrasound scores and dry body mass difference values of patients with different NT-proBNP levels were compared,and the relationship of serum NT-proBNP with lung ultrasound scores and dry body mass difference val-ues was analyzed.Results There was no significant difference in blood pressure,heart rate and blood biochemical indicators between the two groups(P＞0.05).The total incidence of adverse reactions in the observation group was32.00%(16/50),which was higher than that in the control group,with an incidence of 14.00%(7/50,P＜0.05).At the time of enrollment and 3 months after enrollment,the number of A-lines in the observation group was smaller than that in the control group,while the number of B-lines was larger,and lung ultrasound score,water load,edema index,and dry body mass difference were higher than those in the control group(P＜0.05).Before hemodialysis,the serum NT proBNP levels in the observation group were higher than those in the control group(P＜0.05).At the time of enrollment and3 months after enrollment,the pulmo-nary ultrasound scores and dry body mass differences in the high NT-proBNP subgroup were higher than those in the low NT-proBNP subgroup(P＜0.05).According to the Spearman correlation coefficient analysis,serum NT-proBNP in uremic pa-tients undergoing peritoneal dialysis was positively correlated with dry body mass difference and lung ultrasound scores(P＜0.05).Conclusion Both lung ultrasound and human body composition analysis can assess the volume load in patients with uremia undergoing peritoneal dialysis.Patients with high volume load have abnormally elevated serum NT-proBNP levels,which are closely related to lung ultrasound scores and dry body mass differences.Lung ultrasound and body composition anal-ysis can effectively guide the development of treatment plans for patients,improve prognosis,and have certain clinical applica-tion value.
关键词
腹膜透析/尿毒症/容量负荷/人体成分/肺部超声/N末端脑钠肽前体/干体质量差值/相关性
Key words
Peritoneal dialysis/Uremia/Volume load/Body composition/Lung ultrasound/N-terminal pro-brain natriuretic peptide/Dry body mass difference/Correlation
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