Relationship between Pulmonary CT Signs and Th17/Treg Imbalance in Patients with Acquired Immune Deficiency Syndrome Complicated with Pulmonary Tuberculosis
Relationship between Pulmonary CT Signs and Th17/Treg Imbalance in Patients with Acquired Immune Deficiency Syndrome Complicated with Pulmonary Tuberculosis
Objective To investigate the relationship between pulmonary CT signs and the imbalance of helper T cell 17(Th17)/regulatory T cell(Treg)in patients with acquired immune deficiency syndrome(AIDS)complicated with pulmo-nary tuberculosis(PTB).Methods From June 2015 to June 2019,58 patients with AIDS combined with PTB were selected as the observation group,and 30 patients with simple PTB were selected as the control group.Pulmonary CT signs in the two groups were observed.The proportion of Th17 and Treg in peripheral blood was measured by flow cytometry and the Th17/Treg ratio was calculated.Serum levels of interleukin-17(IL-17)and interleukin-10(IL-10)were determined by enzyme-linked immunosorbent assay.The relationship between Th17/Treg ratio in peripheral blood and pulmonary CT signs of atypical PTB was analyzed.Results Compared with the control group,the observation group had diffuse miliary shadow,multiple cavi-ties,multi-segmental exudation,pleural effusion,enlargement of hilar and mediastinal lymph nodes,significantly increased proportion of lesions in more than two lung segments,and significantly decreased incidence of pulmonary calcification shadow(P＜0.05,P＜0.01).Compared with the control group,Th17 proportion,Th17/Treg ratio and serum IL-17 level in periph-eral blood of observation group were significantly decreased,while Treg proportion and serum IL-10 level were increased(P＜0.05).The lower the Th17/Treg ratio,the higher the incidence of pulmonary CT signs of atypical PTB(P＜0.01).Conclu-sion The proportion of atypical pulmonary CT signs and Th17/Treg imbalance are high in AIDS patients with PTB.The com-bination of pulmonary CT signs combined with Th17/Treg ratio has good clinical value in AIDS patients with pulmonary CT signs.
维普
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